Abstract
Purpose: To better understand the relevance of environmental factors to the changing patterns of bone cancer subtypes, we examine the incidence of osteosarcoma (OS), Ewing sarcoma (ES), and chondrosarcoma (CS) using data from cancer incidence in five continents.
Methods: Age-specific and age-standardized incidence rates (ASRs) per
100,000 person-years were computed and stratified by country (n = 43), subtype,
and sex during 2003–2007. Temporal patterns of ASRs were examined during
1988–2007 (12 countries). Age–period–cohort models were fitted for the USA and
UK by subtype.
Results: For most countries, OS represented 20–40 % of all bone
cancers, ES < 20 %, while CS proportions varied more considerably. Overall
ASRs of bone cancers were 0.8–1.2/100,000 in men and 0.5–1.0 in women
(0.20–0.35/100,000 for OS and 0.10–0.30/100,000 for CS in both men and women,
and <0.10–0.25/100,000 in men and 0.05–0.25/100,000 in women for ES). The
age-specific incidence rates revealed a bimodal peak of OS, one peak of ES in
childhood, and a more heterogeneous pattern for CS. The overall bone cancer incidence
trends are generally flat, but more heterogeneous for ES and CS. A declining OS
incidence was observed in the UK and USA (men), an increase in CS in the UK and
USA (female), and an apparent increase in ES, followed by a leveling off in
successive US and UK cohorts.
Conclusion: Monitoring bone cancer incidence trends with data assembled
from a geographically broader range of registries may generate hypotheses about
additional risk factors and ensure that high-risk populations are not
overlooked in cancer control efforts.
Original language | English |
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Pages (from-to) | 1127-1139 |
Number of pages | 13 |
Journal | Cancer Causes and Control |
Volume | 26 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2015 |