Abstract
Purpose: To better understand the relevance of environmental factors to the changing patterns of bone cancer subtypes, we examine the incidence of osteosarcoma (OS), Ewing sarcoma (ES), and chondrosarcoma (CS) using data from cancer incidence in five continents.
Methods: Age-specific and age-standardized incidence rates (ASRs) per
100,000 person-years were computed and stratified by country (n = 43), subtype,
and sex during 2003–2007. Temporal patterns of ASRs were examined during
1988–2007 (12 countries). Age–period–cohort models were fitted for the USA and
UK by subtype.
Results: For most countries, OS represented 20–40 % of all bone
cancers, ES < 20 %, while CS proportions varied more considerably. Overall
ASRs of bone cancers were 0.8–1.2/100,000 in men and 0.5–1.0 in women
(0.20–0.35/100,000 for OS and 0.10–0.30/100,000 for CS in both men and women,
and <0.10–0.25/100,000 in men and 0.05–0.25/100,000 in women for ES). The
age-specific incidence rates revealed a bimodal peak of OS, one peak of ES in
childhood, and a more heterogeneous pattern for CS. The overall bone cancer incidence
trends are generally flat, but more heterogeneous for ES and CS. A declining OS
incidence was observed in the UK and USA (men), an increase in CS in the UK and
USA (female), and an apparent increase in ES, followed by a leveling off in
successive US and UK cohorts.
Conclusion: Monitoring bone cancer incidence trends with data assembled
from a geographically broader range of registries may generate hypotheses about
additional risk factors and ensure that high-risk populations are not
overlooked in cancer control efforts.
| Original language | English |
|---|---|
| Pages (from-to) | 1127-1139 |
| Number of pages | 13 |
| Journal | Cancer Causes and Control |
| Volume | 26 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2015 |
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Bone cancer incidence by morphological subtype : a global assessment. / Valery, Patricia ; Laversanne, Mathieu; Bray, Freddie.
In: Cancer Causes and Control, Vol. 26, No. 8, 08.2015, p. 1127-1139.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Bone cancer incidence by morphological subtype
T2 - a global assessment
AU - Valery, Patricia
AU - Laversanne, Mathieu
AU - Bray, Freddie
PY - 2015/8
Y1 - 2015/8
N2 - Purpose: To better understand the relevance of environmental factors to the changing patterns of bone cancer subtypes, we examine the incidence of osteosarcoma (OS), Ewing sarcoma (ES), and chondrosarcoma (CS) using data from cancer incidence in five continents. Methods: Age-specific and age-standardized incidence rates (ASRs) per 100,000 person-years were computed and stratified by country (n = 43), subtype, and sex during 2003–2007. Temporal patterns of ASRs were examined during 1988–2007 (12 countries). Age–period–cohort models were fitted for the USA and UK by subtype. Results: For most countries, OS represented 20–40 % of all bone cancers, ES < 20 %, while CS proportions varied more considerably. Overall ASRs of bone cancers were 0.8–1.2/100,000 in men and 0.5–1.0 in women (0.20–0.35/100,000 for OS and 0.10–0.30/100,000 for CS in both men and women, and <0.10–0.25/100,000 in men and 0.05–0.25/100,000 in women for ES). The age-specific incidence rates revealed a bimodal peak of OS, one peak of ES in childhood, and a more heterogeneous pattern for CS. The overall bone cancer incidence trends are generally flat, but more heterogeneous for ES and CS. A declining OS incidence was observed in the UK and USA (men), an increase in CS in the UK and USA (female), and an apparent increase in ES, followed by a leveling off in successive US and UK cohorts. Conclusion: Monitoring bone cancer incidence trends with data assembled from a geographically broader range of registries may generate hypotheses about additional risk factors and ensure that high-risk populations are not overlooked in cancer control efforts.
AB - Purpose: To better understand the relevance of environmental factors to the changing patterns of bone cancer subtypes, we examine the incidence of osteosarcoma (OS), Ewing sarcoma (ES), and chondrosarcoma (CS) using data from cancer incidence in five continents. Methods: Age-specific and age-standardized incidence rates (ASRs) per 100,000 person-years were computed and stratified by country (n = 43), subtype, and sex during 2003–2007. Temporal patterns of ASRs were examined during 1988–2007 (12 countries). Age–period–cohort models were fitted for the USA and UK by subtype. Results: For most countries, OS represented 20–40 % of all bone cancers, ES < 20 %, while CS proportions varied more considerably. Overall ASRs of bone cancers were 0.8–1.2/100,000 in men and 0.5–1.0 in women (0.20–0.35/100,000 for OS and 0.10–0.30/100,000 for CS in both men and women, and <0.10–0.25/100,000 in men and 0.05–0.25/100,000 in women for ES). The age-specific incidence rates revealed a bimodal peak of OS, one peak of ES in childhood, and a more heterogeneous pattern for CS. The overall bone cancer incidence trends are generally flat, but more heterogeneous for ES and CS. A declining OS incidence was observed in the UK and USA (men), an increase in CS in the UK and USA (female), and an apparent increase in ES, followed by a leveling off in successive US and UK cohorts. Conclusion: Monitoring bone cancer incidence trends with data assembled from a geographically broader range of registries may generate hypotheses about additional risk factors and ensure that high-risk populations are not overlooked in cancer control efforts.
KW - age
KW - Article
KW - bone cancer
KW - cancer classification
KW - cancer diagnosis
KW - cancer epidemiology
KW - cancer incidence
KW - cancer risk
KW - childhood
KW - chondrosarcoma
KW - cohort analysis
KW - Ewing sarcoma
KW - geographic distribution
KW - human
KW - longitudinal study
KW - osteosarcoma
KW - priority journal
KW - risk factor
KW - sex difference
KW - trend study
KW - United Kingdom
KW - United States
KW - adolescent
KW - adult
KW - aged
KW - Bone Neoplasms
KW - child
KW - female
KW - incidence
KW - infant
KW - male
KW - middle aged
KW - newborn
KW - preschool child
KW - register
KW - very elderly
KW - young adult
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Child
KW - Child, Preschool
KW - Chondrosarcoma
KW - Female
KW - Great Britain
KW - Humans
KW - Incidence
KW - Infant
KW - Infant, Newborn
KW - Male
KW - Middle Aged
KW - Osteosarcoma
KW - Registries
KW - Risk Factors
KW - Young Adult
U2 - 10.1007/s10552-015-0607-3
DO - 10.1007/s10552-015-0607-3
M3 - Article
VL - 26
SP - 1127
EP - 1139
JO - Cancer Causes and Control
JF - Cancer Causes and Control
SN - 0957-5243
IS - 8
ER -