Brensocatib in Bronchiectasis - A New Sheriff in Town?

Bronchiectasis unrelated to cystic fibrosis is the third most common chronic pulmonary disorder after asthma and chronic obstructive pulmonary disease.1 Bronchiectasis has multiple causes and is characterized by recurrent and often chronic productive cough, lower airway infection and inflammation, and irreversible bronchial dilatation.2 Irrespective of the cause, mucociliary dysfunction, infection, dysregulated inflammation, and airway parenchymal injury are interlinked in a mechanistic "vicious vortex"model, which suggests that all four components are targets for therapy (see Fig. 1 in the Science behind the Study editorial by Hill3 in this issue of the Journal). As with other chronic airway diseases, acute clinical.