Bronchiectasis and Chronic Suppurative Lung Disease

Anne B. Chang, Gregory J. Redding

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Abstract

Bronchiectasis, chronic suppurative lung disease, and protracted bacterial bronchitis (PBB) are increasingly recognized conditions. Bronchiectasis is now again increasingly diagnosed, and its renewed interest has resulted in further in-depth studies in children and adults. However, diagnostic labeling of childhood bronchiectasis by radiology using adult-derived criteria has substantial limitations. Thus, pediatric-derived criteria are advocated. A paradigm presenting a spectrum related to airway bacteria, with associated degradation and inflammation products causing airway damage if untreated, entails PBB (at the mild end) to irreversible airway dilatation with cystic formation as determined by chest computed tomography (CT) scan (at the severe end of the spectrum). Increasing evidence suggest that progression of airway damage can be limited by intensive treatment, even in those predestined to have bronchiectasis (e.g., immune deficiency). Treatment is aimed at achieving a cure in those at the milder end of the spectrum to limiting further deterioration in those with severe "irreversible" radiological bronchiectasis.Anne Chang is supported by Australian National Health and Medical Research Council practitioner fellowship (1058213), Centre for Research Excellence grant (1040830) and project grants (1098443 and 1019834).Greg Redding is supported in part by Maternal Child Health Grant T72MC00007.

LanguageEnglish
Title of host publicationKendig's Disorders of the Respiratory Tract in Children
EditorsRobert Wilmott , Andrew Bush , Robin Deterding , Felix Ratjen , Peter Sly , Heather Zar, Albert Li
PublisherElsevier
Chapter26
Pages439-459.e6
Number of pages21
Edition9th
ISBN (Electronic)9780323555951
ISBN (Print)9780323448871
StatePublished - 2019

Fingerprint

Bronchiectasis
Lung Diseases
Bronchitis
Organized Financing
Radiology
Biomedical Research
Dilatation
Thorax
Tomography
Pediatrics
Inflammation
Bacteria
Health
Therapeutics
Research

Cite this

Chang, A. B., & Redding, G. J. (2019). Bronchiectasis and Chronic Suppurative Lung Disease. In R. Wilmott , A. Bush , R. Deterding , F. Ratjen , P. Sly , H. Zar, & A. Li (Eds.), Kendig's Disorders of the Respiratory Tract in Children (9th ed., pp. 439-459.e6). Elsevier.
Chang, Anne B. ; Redding, Gregory J./ Bronchiectasis and Chronic Suppurative Lung Disease. Kendig's Disorders of the Respiratory Tract in Children. editor / Robert Wilmott ; Andrew Bush ; Robin Deterding ; Felix Ratjen ; Peter Sly ; Heather Zar ; Albert Li. 9th. ed. Elsevier, 2019. pp. 439-459.e6
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Chang, AB & Redding, GJ 2019, Bronchiectasis and Chronic Suppurative Lung Disease. in R Wilmott , A Bush , R Deterding , F Ratjen , P Sly , H Zar & A Li (eds), Kendig's Disorders of the Respiratory Tract in Children. 9th edn, Elsevier, pp. 439-459.e6.

Bronchiectasis and Chronic Suppurative Lung Disease. / Chang, Anne B.; Redding, Gregory J.

Kendig's Disorders of the Respiratory Tract in Children. ed. / Robert Wilmott ; Andrew Bush ; Robin Deterding ; Felix Ratjen ; Peter Sly ; Heather Zar; Albert Li. 9th. ed. Elsevier, 2019. p. 439-459.e6.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

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AU - Redding,Gregory J.

PY - 2019

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AB - Bronchiectasis, chronic suppurative lung disease, and protracted bacterial bronchitis (PBB) are increasingly recognized conditions. Bronchiectasis is now again increasingly diagnosed, and its renewed interest has resulted in further in-depth studies in children and adults. However, diagnostic labeling of childhood bronchiectasis by radiology using adult-derived criteria has substantial limitations. Thus, pediatric-derived criteria are advocated. A paradigm presenting a spectrum related to airway bacteria, with associated degradation and inflammation products causing airway damage if untreated, entails PBB (at the mild end) to irreversible airway dilatation with cystic formation as determined by chest computed tomography (CT) scan (at the severe end of the spectrum). Increasing evidence suggest that progression of airway damage can be limited by intensive treatment, even in those predestined to have bronchiectasis (e.g., immune deficiency). Treatment is aimed at achieving a cure in those at the milder end of the spectrum to limiting further deterioration in those with severe "irreversible" radiological bronchiectasis.Anne Chang is supported by Australian National Health and Medical Research Council practitioner fellowship (1058213), Centre for Research Excellence grant (1040830) and project grants (1098443 and 1019834).Greg Redding is supported in part by Maternal Child Health Grant T72MC00007.

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BT - Kendig's Disorders of the Respiratory Tract in Children

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Chang AB, Redding GJ. Bronchiectasis and Chronic Suppurative Lung Disease. In Wilmott R, Bush A, Deterding R, Ratjen F, Sly P, Zar H, Li A, editors, Kendig's Disorders of the Respiratory Tract in Children. 9th ed. Elsevier. 2019. p. 439-459.e6.