Bronchiectasis and Chronic Suppurative Lung Disease

Anne B. Chang, Gregory J. Redding

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    Abstract

    Bronchiectasis, chronic suppurative lung disease, and protracted bacterial bronchitis (PBB) are increasingly recognized conditions. Bronchiectasis is now again increasingly diagnosed, and its renewed interest has resulted in further in-depth studies in children and adults. However, diagnostic labeling of childhood bronchiectasis by radiology using adult-derived criteria has substantial limitations. Thus, pediatric-derived criteria are advocated. A paradigm presenting a spectrum related to airway bacteria, with associated degradation and inflammation products causing airway damage if untreated, entails PBB (at the mild end) to irreversible airway dilatation with cystic formation as determined by chest computed tomography (CT) scan (at the severe end of the spectrum). Increasing evidence suggest that progression of airway damage can be limited by intensive treatment, even in those predestined to have bronchiectasis (e.g., immune deficiency). Treatment is aimed at achieving a cure in those at the milder end of the spectrum to limiting further deterioration in those with severe "irreversible" radiological bronchiectasis.Anne Chang is supported by Australian National Health and Medical Research Council practitioner fellowship (1058213), Centre for Research Excellence grant (1040830) and project grants (1098443 and 1019834).Greg Redding is supported in part by Maternal Child Health Grant T72MC00007.

    Original languageEnglish
    Title of host publicationKendig's Disorders of the Respiratory Tract in Children
    EditorsRobert Wilmott , Andrew Bush , Robin Deterding , Felix Ratjen , Peter Sly , Heather Zar, Albert Li
    Place of PublicationPhiladelphia
    PublisherElsevier
    Chapter26
    Pages439-459
    Number of pages21
    Edition9th
    ISBN (Electronic)9780323555951
    ISBN (Print)9780323448871
    DOIs
    Publication statusPublished - 8 Mar 2018

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