Burkholderia pseudomallei and Burkholderia mallei: Melioidosis and glanders

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The genus Burkholderia is currently composed of many species, but only three are notable pathogens for humans or animals: the former cepacia complex (described in Chapter 220) pseudomallei (the agent of melioidosis), and mallei (the agent of equine glanders). All three are aerobic, nonsporulating, straight or slightly curved gram-negative bacilli that were formerly placed in the genus Pseudomonas. Melioidosis Melioidosis is a disease of humans and animals; it has enormous clini-cal diversity, spanning asymptomatic infection, localized skin ulcers or abscesses, chronic pneumonia mimicking tuberculosis, and fulminant septic shock with abscesses in multiple internal organs. Most disease is from recent infection, but latency with reactivation is described up to 62 years after exposure. Most cases are reported from Southeast Asia and northern Australia, but melioidosis is increasingly being recog-nized in people infected in an endemic region who return or travel to Europe and the United States. The causative bacterium, Burkholderia pseudomallei, is also considered a potential biologic warfare agent.
Original languageEnglish
Title of host publicationPrinciples and Practice of Infectious Diseases
EditorsGerald Mandell, John Bennett, Raphael Dolin
Place of PublicationPhiladelphia
Number of pages11
ISBN (Print)9781455748013
Publication statusPublished - 2015


Dive into the research topics of 'Burkholderia pseudomallei and Burkholderia mallei: Melioidosis and glanders'. Together they form a unique fingerprint.

Cite this