C-reactive protein in the diagnosis of melioidosis

A CHENG, M O'Brien, Susan Jacups, Nicholas Anstey, Bart Currie

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Previous work suggested that C-reactive protein (CRP) may be a useful test in the diagnosis of melioidosis, the infection caused by Burkholderia pseudomallei. We reviewed patients with culture-confirmed melioidosis to define the role of this inflammatory marker in the diagnosis of melioidosis. In 175 patients, we found that the admission CRP level may be normal or only mildly elevated, including patients with severe sepsis, fatal cases, and in relapsed melioidosis. In a multivariate analysis, sepsis and bacteremia were more strongly associated with mortality than CRP. Admission levels of CRP are not a sensitive marker for the presence of melioidosis and a normal level cannot be used to exclude acute, chronic, or relapsed melioidosis in febrile patients in or from endemic regions.
    Original languageEnglish
    Pages (from-to)580-582
    Number of pages3
    JournalAmerican Journal of Tropical Medicine and Hygiene
    Volume70
    Issue number5
    Publication statusPublished - 2004

    Fingerprint

    Melioidosis
    C-Reactive Protein
    Sepsis
    Burkholderia pseudomallei
    Patient Admission
    Bacteremia
    Fever
    Multivariate Analysis
    Mortality
    Infection

    Cite this

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    title = "C-reactive protein in the diagnosis of melioidosis",
    abstract = "Previous work suggested that C-reactive protein (CRP) may be a useful test in the diagnosis of melioidosis, the infection caused by Burkholderia pseudomallei. We reviewed patients with culture-confirmed melioidosis to define the role of this inflammatory marker in the diagnosis of melioidosis. In 175 patients, we found that the admission CRP level may be normal or only mildly elevated, including patients with severe sepsis, fatal cases, and in relapsed melioidosis. In a multivariate analysis, sepsis and bacteremia were more strongly associated with mortality than CRP. Admission levels of CRP are not a sensitive marker for the presence of melioidosis and a normal level cannot be used to exclude acute, chronic, or relapsed melioidosis in febrile patients in or from endemic regions.",
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    C-reactive protein in the diagnosis of melioidosis. / CHENG, A; O'Brien, M; Jacups, Susan; Anstey, Nicholas; Currie, Bart.

    In: American Journal of Tropical Medicine and Hygiene, Vol. 70, No. 5, 2004, p. 580-582.

    Research output: Contribution to journalArticleResearchpeer-review

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