Calcitonin gene-related peptide relates to cough sensitivity in children with chronic cough

Anne Chang, Peter Gibson, J Ardill, L McGarvey

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Airway neuropeptides, in particular calcitonin gene-related peptide (CGRP), are likely to be important in the pathogenesis of chronic cough. The present authors evaluated the following: 1) the relationship between cough sensitivity and bronchoalveolar lavage (BAL) neuropeptides; and 2) the effect of reflux oesophagitis (RO) on cough, cough sensitivity and BAL neuropeptides in children not selected for cough. It was hypothesised that CGRP would be increased in children with chronic cough and would relate to cough sensitivity. Capsaicin cough sensitivity was performed in children undergoing gastro-duodenal endoscopy. CGRP, substance P and neurokinin A were measured in BAL obtained nonbronchoscopically. Children were defined as "coughers" if chronic cough was present. Coughers (n=21) had significantly reduced cough sensitivity but were just as likely as noncoughers (n=19) to have RO. The median CGRP was significantly higher in coughers with oesophagitis than in noncoughers with oesophagitis. CGRP significantly negatively correlated to cough sensitivity in coughers but not in noncoughers. Elevated calcitonin gene-related peptide, but not substance P or neurokinin A, is only associated with chronic cough in children when oesophagitis coexists. Calcitonin gene-related peptide in bronchoalveolar lavage relates to cough sensitivity and is likely to be important in the pathophysiology of chronic cough. Copyright � ERS Journals Ltd 2007.
Original languageEnglish
Pages (from-to)66-72
Number of pages7
JournalEuropean Respiratory Journal
Volume30
Issue number1
Publication statusPublished - 2007

Fingerprint

Calcitonin Gene-Related Peptide
Cough
Bronchoalveolar Lavage
Esophagitis
Neuropeptides
Neurokinin A
Peptic Esophagitis
Substance P
Capsaicin
Endoscopy

Cite this

Chang, Anne ; Gibson, Peter ; Ardill, J ; McGarvey, L. / Calcitonin gene-related peptide relates to cough sensitivity in children with chronic cough. In: European Respiratory Journal. 2007 ; Vol. 30, No. 1. pp. 66-72.
@article{fbfcfecff48747289b8674cbf364ffd6,
title = "Calcitonin gene-related peptide relates to cough sensitivity in children with chronic cough",
abstract = "Airway neuropeptides, in particular calcitonin gene-related peptide (CGRP), are likely to be important in the pathogenesis of chronic cough. The present authors evaluated the following: 1) the relationship between cough sensitivity and bronchoalveolar lavage (BAL) neuropeptides; and 2) the effect of reflux oesophagitis (RO) on cough, cough sensitivity and BAL neuropeptides in children not selected for cough. It was hypothesised that CGRP would be increased in children with chronic cough and would relate to cough sensitivity. Capsaicin cough sensitivity was performed in children undergoing gastro-duodenal endoscopy. CGRP, substance P and neurokinin A were measured in BAL obtained nonbronchoscopically. Children were defined as {"}coughers{"} if chronic cough was present. Coughers (n=21) had significantly reduced cough sensitivity but were just as likely as noncoughers (n=19) to have RO. The median CGRP was significantly higher in coughers with oesophagitis than in noncoughers with oesophagitis. CGRP significantly negatively correlated to cough sensitivity in coughers but not in noncoughers. Elevated calcitonin gene-related peptide, but not substance P or neurokinin A, is only associated with chronic cough in children when oesophagitis coexists. Calcitonin gene-related peptide in bronchoalveolar lavage relates to cough sensitivity and is likely to be important in the pathophysiology of chronic cough. Copyright � ERS Journals Ltd 2007.",
keywords = "calcitonin gene related peptide, capsaicin, neurokinin A, substance P, article, bronchoscopy, child, child health, controlled study, coughing, female, gastrointestinal endoscopy, human, lung lavage, major clinical study, male, pathogenesis, priority journal, reflux esophagitis, Bronchoalveolar Lavage, Calcitonin Gene-Related Peptide, Capsaicin, Child, Child, Preschool, Chronic Disease, Cough, Endoscopy, Esophagitis, Peptic, Female, Humans, Male, Models, Statistical, Neuropeptides, Peptides",
author = "Anne Chang and Peter Gibson and J Ardill and L McGarvey",
year = "2007",
language = "English",
volume = "30",
pages = "66--72",
journal = "European Respiratory Journal",
issn = "0903-1936",
publisher = "Unknown",
number = "1",

}

Calcitonin gene-related peptide relates to cough sensitivity in children with chronic cough. / Chang, Anne; Gibson, Peter; Ardill, J; McGarvey, L.

In: European Respiratory Journal, Vol. 30, No. 1, 2007, p. 66-72.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Calcitonin gene-related peptide relates to cough sensitivity in children with chronic cough

AU - Chang, Anne

AU - Gibson, Peter

AU - Ardill, J

AU - McGarvey, L

PY - 2007

Y1 - 2007

N2 - Airway neuropeptides, in particular calcitonin gene-related peptide (CGRP), are likely to be important in the pathogenesis of chronic cough. The present authors evaluated the following: 1) the relationship between cough sensitivity and bronchoalveolar lavage (BAL) neuropeptides; and 2) the effect of reflux oesophagitis (RO) on cough, cough sensitivity and BAL neuropeptides in children not selected for cough. It was hypothesised that CGRP would be increased in children with chronic cough and would relate to cough sensitivity. Capsaicin cough sensitivity was performed in children undergoing gastro-duodenal endoscopy. CGRP, substance P and neurokinin A were measured in BAL obtained nonbronchoscopically. Children were defined as "coughers" if chronic cough was present. Coughers (n=21) had significantly reduced cough sensitivity but were just as likely as noncoughers (n=19) to have RO. The median CGRP was significantly higher in coughers with oesophagitis than in noncoughers with oesophagitis. CGRP significantly negatively correlated to cough sensitivity in coughers but not in noncoughers. Elevated calcitonin gene-related peptide, but not substance P or neurokinin A, is only associated with chronic cough in children when oesophagitis coexists. Calcitonin gene-related peptide in bronchoalveolar lavage relates to cough sensitivity and is likely to be important in the pathophysiology of chronic cough. Copyright � ERS Journals Ltd 2007.

AB - Airway neuropeptides, in particular calcitonin gene-related peptide (CGRP), are likely to be important in the pathogenesis of chronic cough. The present authors evaluated the following: 1) the relationship between cough sensitivity and bronchoalveolar lavage (BAL) neuropeptides; and 2) the effect of reflux oesophagitis (RO) on cough, cough sensitivity and BAL neuropeptides in children not selected for cough. It was hypothesised that CGRP would be increased in children with chronic cough and would relate to cough sensitivity. Capsaicin cough sensitivity was performed in children undergoing gastro-duodenal endoscopy. CGRP, substance P and neurokinin A were measured in BAL obtained nonbronchoscopically. Children were defined as "coughers" if chronic cough was present. Coughers (n=21) had significantly reduced cough sensitivity but were just as likely as noncoughers (n=19) to have RO. The median CGRP was significantly higher in coughers with oesophagitis than in noncoughers with oesophagitis. CGRP significantly negatively correlated to cough sensitivity in coughers but not in noncoughers. Elevated calcitonin gene-related peptide, but not substance P or neurokinin A, is only associated with chronic cough in children when oesophagitis coexists. Calcitonin gene-related peptide in bronchoalveolar lavage relates to cough sensitivity and is likely to be important in the pathophysiology of chronic cough. Copyright � ERS Journals Ltd 2007.

KW - calcitonin gene related peptide

KW - capsaicin

KW - neurokinin A

KW - substance P

KW - article

KW - bronchoscopy

KW - child

KW - child health

KW - controlled study

KW - coughing

KW - female

KW - gastrointestinal endoscopy

KW - human

KW - lung lavage

KW - major clinical study

KW - male

KW - pathogenesis

KW - priority journal

KW - reflux esophagitis

KW - Bronchoalveolar Lavage

KW - Calcitonin Gene-Related Peptide

KW - Capsaicin

KW - Child

KW - Child, Preschool

KW - Chronic Disease

KW - Cough

KW - Endoscopy

KW - Esophagitis, Peptic

KW - Female

KW - Humans

KW - Male

KW - Models, Statistical

KW - Neuropeptides

KW - Peptides

M3 - Article

VL - 30

SP - 66

EP - 72

JO - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

IS - 1

ER -