Cardiac function and responsiveness to beta-adrenoceptor agonists in rats with obstructive jaundice

G. Jacob, N. Nassar, G. Hayam, S. Ben-Haim, Y. Edoute, O. S. Better, A. Bomzon

Research output: Contribution to journalArticlepeer-review


The function and role of the heart and the contribution of cardiac beta-adrenoceptors in the pathogenesis of circulatory failure in obstructive jaundice were studied in the 3-day bile duct-ligated (BDL) rat using three different techniques to measure cardiac function and beta-adrenoceptor activity, number, and affinity. The techniques were the pithed rat preparation, the isolated working heart preparation, and a competitive radioligand binding assay for beta-adrenoceptors. The results of these experiments were compared with those obtained in 3-day bile duct-manipulated (sham operated; SO) rats. Impaired indexes of basal cardiac contractility were observed in the BDL pithed rats and isolated working hearts. In these two preparations, responsiveness to norepinephrine and the beta-adrenoceptor agonists, isoproterenol and dobutamine, was unaffected by bile duct ligation. The affinity and number of cardiac beta-adrenoceptors in membranes from the hearts of SO and BDL rats were not significantly different from each other. These experiments have established for the first time that the 3-day BDL rat has a cardiac myopathy associated with intact responsiveness to beta-adrenoceptor agonists, a normal unchanged affinity and number of cardiac beta-adrenoceptors.
Original languageEnglish
Pages (from-to)G314-G320
JournalAmerican Journal of Physiology: Gastrointestinal and Liver Physiology
Issue number2
Publication statusPublished - 1993


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