Carotid extramedial thickness is associated with local arterial stiffness in children

Tommy Y. Cai, Tim R. Sullivan, Julian G. Ayer, Jason A. Harmer, Stephen R. Leeder, Brett G. Toelle, Guy B. Marks, David S. Celermajer, Michael R. Skilton, Anna L. Hansell, Nectarios Rose, Christine T. Cowie, Elena G. Belousova, Ioannis Bakolis, Kitty Ng, Catarina Almqvist, Rosario D. Ampon, Tessa Bird, Bronwyn K. Brew, Warwick J. BrittonChristopher T. Cowell, Daniele Crisafulli, Sally Criss, Stella Davis, Wafaa Nabil Ezz, Samantha Forbes, Frances L. Garden, Andrew S. Kemp, Natalia Knezevic, William Krause, Craig M Mellis, Seema Mihrshahi, Mark Neumann, Jennifer K. Peat, Andres Quinones-Lucio, Anne Tattam, Euan R. Tovey, Carl H. Vanlaar, Nicola Vukasin, Craig Wainwright, Karen L. Webb, Christina Weber-Chrysochoou, Ann J. Woolcock, Jie Zhou

Research output: Contribution to journalArticle

Abstract

Objectives: Experimental evidence suggests that structuralchanges to the arterial adventitia may be a key vascular determinant of earlyarterial stiffening, although this has not been directly studied. Accordingly,we hypothesized that in young children, in whom this relationship would not bealtered by atheroma, carotid extramedial thickness (EMT), a measure thatincorporates the thickness of the arterial adventitia, perivascular tissues andthe internal jugular venous wall, would be associated with localized arterialstiffness of the same arterial region.

Methods: We studied 248 healthy prepubescent children (aged8 years). Carotid diameter and carotid EMT were measured by high-resolutionultrasound. Carotid blood pressure was derived from brachial blood pressure andcarotid tonometry. Three measures of localized arterial stiffness (β stiffnessindex, distensibility coefficient and incremental modulus of elasticity) werecalculated for the common carotid artery. Results were adjusted for heart rateand DBP, two important hemodynamic determinants of arterial stiffness.

Results: Carotid EMT was associated with all three measuresof arterial stiffness (β stiffness index: standardized β = 0.121, P = 0.03;distensibility coefficient: standardized β = -0.121, P = 0.05; incrementalmodulus of elasticity: standardized β = 0.140, P = 0.02). These associationsremained significant after adjustment for potential confounders such as sex,height, waist circumference, BMI and body surface area.

Conclusion: Carotid EMT is associated with the stiffness ofthe same arterial segment in children, suggesting that the arterial adventitiamay be involved in early changes in arterial stiffness during childhood.

 

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalJournal of Hypertension
Volume34
Issue number1
DOIs
Publication statusPublished - 1 Jan 2016
Externally publishedYes

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    Cai, T. Y., Sullivan, T. R., Ayer, J. G., Harmer, J. A., Leeder, S. R., Toelle, B. G., Marks, G. B., Celermajer, D. S., Skilton, M. R., Hansell, A. L., Rose, N., Cowie, C. T., Belousova, E. G., Bakolis, I., Ng, K., Almqvist, C., Ampon, R. D., Bird, T., Brew, B. K., ... Zhou, J. (2016). Carotid extramedial thickness is associated with local arterial stiffness in children. Journal of Hypertension, 34(1), 109-115. https://doi.org/10.1097/HJH.0000000000000769