Case Report: A Case of Primaquine-Induced Hemoglobinuria in Glucose-6-Phosphate Dehydrogenase Deficient Malaria Patient in Southeastern Bangladesh

Ching Swe Phru, Mohammad Golam Kibria, Kamala Thriemer, Mahtab Uddin Chowdhury, Nusrat Jahan, M. M. Aktaruzzaman, Hisni Rahmat, Ari Winasti Satyagraha, Aung Swi Prue, Wasif Ali Khan, Benedikt Ley, Mohammad Shafiul Alam

    Research output: Contribution to journalArticle

    Abstract

    We herein report the first case of Mediterranean glucose-6-phosphate dehydrogenase (G6PD) variant from Bangladesh. A boy had been admitted to hospital and was diagnosed with uncomplicated Plasmodium vivax infection and treated with 30 mg/kg body weight (BW) chloroquine for 3 days and 4.8 mg/kg BW primaquine (PQ) to be taken over 14 days. The boy was discharged but represented 4 days later with severe hemoglobinuria and fatigue. Hemoglobin was measured at 6.0 g/dL and serum bilirubin was at 5.6 mg/dL, although malaria microscopy was negative. The boy had taken the 4-fold recommended daily dose of PQ and was treated with two fresh blood transfusions. Subsequent molecular analysis showed the boy to have the Mediterranean G6PD variant and a G6PD activity of 0.93 U/gHb.

    Original languageEnglish
    Pages (from-to)156-158
    Number of pages3
    JournalThe American Journal of Tropical Medicine and Hygiene
    Volume102
    Issue number1
    DOIs
    Publication statusPublished - 8 Jan 2020

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    Phru, C. S., Kibria, M. G., Thriemer, K., Chowdhury, M. U., Jahan, N., Aktaruzzaman, M. M., Rahmat, H., Satyagraha, A. W., Prue, A. S., Khan, W. A., Ley, B., & Alam, M. S. (2020). Case Report: A Case of Primaquine-Induced Hemoglobinuria in Glucose-6-Phosphate Dehydrogenase Deficient Malaria Patient in Southeastern Bangladesh. The American Journal of Tropical Medicine and Hygiene , 102(1), 156-158. https://doi.org/10.4269/ajtmh.19-0643