Vertical transmission of Plasmodium falciparum is under-recognized and usually associated with asymptom-atic low-level parasitemia at birth. We report symptomatic congenital malaria presenting as a neonatal sepsis syndrome. The presence at birth of a high asexual parasitemia, gametocytemia, and splenomegaly indicated in utero rather than intrapartum transmission. The neonate was successfully treated with intravenous artesunate followed by oral dihydroartemisinin-piperaquine, without apparent adverse effects.
Poespoprodjo, J. R., Hasanuddin, A., Fobia, W., Sugiarto, P., Kenangalem, E., Lampah, D., Tijitra, E., Price, R., & Anstey, N. (2010). Case Report: Severe Congenital Malaria Acquired in Utero. American Journal of Tropical Medicine and Hygiene, 82(4), 563-565. https://doi.org/10.4269/ajtmh.2010.09-0744