Cathepsin B proteases of flukes: the key to facilitating parasite control?

Peter M Smooker, Rama Jayaraj, Robert N Pike, Terry W Spithill

    Research output: Contribution to journalArticlepeer-review


    Cysteine proteases are important virulence factors for parasites. This review will focus on the cathepsin B proteases of trematodes (also known as flukes) which are abundant in juvenile and immature flukes. Recent research, primarily in Fasciola, using inhibitors, RNA interference (RNAi) and vaccination studies indicates that cathepsin Bs play a key role in the biology of trematodes. As these proteases are largely expressed by infective parasite stages, their inactivation by chemotherapy or vaccination will greatly reduce the damage wrought by flukes as they invade host tissues. This validates cathepsin Bs as key strategic targets for fluke control.
    Original languageEnglish
    Pages (from-to)506-514
    Number of pages9
    JournalTrends in Parasitology
    Issue number10
    Publication statusPublished - 2010


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