Cause of Death Varies Across Australia, New Zealand And Malaysia In Those on Renal Replacement Therapy - Results from The Study of Heart and Renal Protection-Extended Review (Sharp-Er)

B. Talbot, L. Sukkar, B. Smyth, M. Jun, M. Jardine, A. Cass, R. Walker, C. Reith, L. Hooi, M. Gallagher

    Research output: Contribution to journalMeeting Abstract


    Background: The mortality rate among dialysis patients is high with regional variability.

    Aim: To compare survival and cause of death between countries in dialysis patients in the SHARP‐ER cohort.

    Method: The Study of Heart and Renal Protection‐Extended Review (SHARP‐ER) comprised extended 5‐year follow up of eligible participants in Australia, New Zealand and Malaysia alive at the end of SHARP (a randomised double‐blind trial of simvastatin and ezetimibe vs. placebo in chronic kidney disease). Cause of death was compared using registry data (national death index (Australia, New Zealand) and national death registry (Malaysia)) for participants receiving chronic dialysis (haemodialysis or peritoneal dialysis) at the beginning of the extended review period. Multivariate survival analysis and multinomial logistic regression were conducted to assess for differences.

    Results: The cohort comprised 1136 eligible participants of whom 526 were receiving dialysis. During the 5 year follow up 203 died (38.6%). Median age was lowest in Malaysia (56.2 years, [50.4‐63.8] followed by New Zealand (60.4 years [55.5‐67.3]) and Australia (66.1 years [55.3‐75.8]). Treating country did not significantly affect survival following adjustment for age, gender and dialysis modality. Cardiovascular disease was the most common cause of death (New Zealand 52.4%, Australia 43.2%, Malaysia 32.6%). Infectious causes of death were significantly more common in Malaysia versus Australia/New Zealand (RR 4.56, p=0.002, 95% CI 1.75‐11.85) following adjustment for age, gender and modality (Crude rates: Malaysia 31.8%, New Zealand 9.5%, Australia 6.8%). Peritoneal dialysis was also associated with an increased risk of infectious death (RR 3.64, p==0.017, 95%CI 1.26‐10.48) following adjustment.

    Conclusion: In the SHARP‐ER cohort, survival on dialysis was comparable between countries but causes of death differed. This suggests a need for region specific interventions.
    Original languageEnglish
    Pages (from-to)29-29
    Number of pages1
    Issue numberS3
    Early online date30 Aug 2018
    Publication statusPublished - 1 Sep 2018


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