Challenges and strategies for developing efficacious and long-lasting malaria vaccines

James G. Beeson, Liriye Kurtovic, Carlota Dobaño, D. Herbert Opi, Jo Anne Chan, Gaoqian Feng, Michael F. Good, Linda Reiling, Michelle J. Boyle

    Research output: Contribution to journalArticle

    Abstract

    Although there has been major recent progress in malaria vaccine development, substantial challenges remain for achieving highly efficacious and durable vaccines against Plasmodium falciparum and Plasmodium vivax malaria. Greater knowledge of mechanisms and key targets of immunity are needed to accomplish this goal, together with new strategies for generating potent, long-lasting, functional immunity against multiple antigens. Implementation considerations in endemic areas will ultimately affect vaccine effectiveness, so innovations to simplify and enhance delivery are also needed. Whereas challenges remain, recent exciting progress and emerging knowledge promise hope for the future of malaria vaccines.

    Original languageEnglish
    Article numbereaau1458
    Pages (from-to)1-17
    Number of pages17
    JournalScience Translational Medicine
    Volume11
    Issue number474
    DOIs
    Publication statusPublished - 9 Jan 2019

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  • Cite this

    Beeson, J. G., Kurtovic, L., Dobaño, C., Opi, D. H., Chan, J. A., Feng, G., Good, M. F., Reiling, L., & Boyle, M. J. (2019). Challenges and strategies for developing efficacious and long-lasting malaria vaccines. Science Translational Medicine, 11(474), 1-17. [eaau1458]. https://doi.org/10.1126/scitranslmed.aau1458