Challenges and strategies for developing efficacious and long-lasting malaria vaccines

James G. Beeson, Liriye Kurtovic, Carlota Dobaño, D. Herbert Opi, Jo Anne Chan, Gaoqian Feng, Michael F. Good, Linda Reiling, Michelle J. Boyle

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Although there has been major recent progress in malaria vaccine development, substantial challenges remain for achieving highly efficacious and durable vaccines against Plasmodium falciparum and Plasmodium vivax malaria. Greater knowledge of mechanisms and key targets of immunity are needed to accomplish this goal, together with new strategies for generating potent, long-lasting, functional immunity against multiple antigens. Implementation considerations in endemic areas will ultimately affect vaccine effectiveness, so innovations to simplify and enhance delivery are also needed. Whereas challenges remain, recent exciting progress and emerging knowledge promise hope for the future of malaria vaccines.

Original languageEnglish
Article numbereaau1458
JournalScience Translational Medicine
Volume11
Issue number474
DOIs
Publication statusPublished - 9 Jan 2019

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Malaria Vaccines
Immunity
Vaccines
Vivax Malaria
Plasmodium falciparum
Antigens

Cite this

Beeson, J. G., Kurtovic, L., Dobaño, C., Opi, D. H., Chan, J. A., Feng, G., ... Boyle, M. J. (2019). Challenges and strategies for developing efficacious and long-lasting malaria vaccines. Science Translational Medicine, 11(474), [eaau1458]. https://doi.org/10.1126/scitranslmed.aau1458
Beeson, James G. ; Kurtovic, Liriye ; Dobaño, Carlota ; Opi, D. Herbert ; Chan, Jo Anne ; Feng, Gaoqian ; Good, Michael F. ; Reiling, Linda ; Boyle, Michelle J. / Challenges and strategies for developing efficacious and long-lasting malaria vaccines. In: Science Translational Medicine. 2019 ; Vol. 11, No. 474.
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Beeson, JG, Kurtovic, L, Dobaño, C, Opi, DH, Chan, JA, Feng, G, Good, MF, Reiling, L & Boyle, MJ 2019, 'Challenges and strategies for developing efficacious and long-lasting malaria vaccines' Science Translational Medicine, vol. 11, no. 474, eaau1458. https://doi.org/10.1126/scitranslmed.aau1458

Challenges and strategies for developing efficacious and long-lasting malaria vaccines. / Beeson, James G.; Kurtovic, Liriye; Dobaño, Carlota; Opi, D. Herbert; Chan, Jo Anne; Feng, Gaoqian; Good, Michael F.; Reiling, Linda; Boyle, Michelle J.

In: Science Translational Medicine, Vol. 11, No. 474, eaau1458, 09.01.2019.

Research output: Contribution to journalArticleResearchpeer-review

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