Challenges and strategies for developing efficacious and long-lasting malaria vaccines

James G. Beeson; Liriye Kurtovic; Carlota Dobaño; D. Herbert Opi; Jo Anne Chan; Gaoqian Feng; Michael F. Good; Linda Reiling; Michelle J. Boyle

doi:10.1126/scitranslmed.aau1458

Challenges and strategies for developing efficacious and long-lasting malaria vaccines

James G. Beeson, Liriye Kurtovic, Carlota Dobaño, D. Herbert Opi, Jo Anne Chan, Gaoqian Feng, Michael F. Good, Linda Reiling, Michelle J. Boyle

Global and Tropical Health

Research output: Contribution to journal › Article › peer-review

Abstract

Although there has been major recent progress in malaria vaccine development, substantial challenges remain for achieving highly efficacious and durable vaccines against Plasmodium falciparum and Plasmodium vivax malaria. Greater knowledge of mechanisms and key targets of immunity are needed to accomplish this goal, together with new strategies for generating potent, long-lasting, functional immunity against multiple antigens. Implementation considerations in endemic areas will ultimately affect vaccine effectiveness, so innovations to simplify and enhance delivery are also needed. Whereas challenges remain, recent exciting progress and emerging knowledge promise hope for the future of malaria vaccines.

Original language	English
Article number	eaau1458
Pages (from-to)	1-17
Number of pages	17
Journal	Science Translational Medicine
Volume	11
Issue number	474
DOIs	https://doi.org/10.1126/scitranslmed.aau1458
Publication status	Published - 9 Jan 2019

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abstract = "Although there has been major recent progress in malaria vaccine development, substantial challenges remain for achieving highly efficacious and durable vaccines against Plasmodium falciparum and Plasmodium vivax malaria. Greater knowledge of mechanisms and key targets of immunity are needed to accomplish this goal, together with new strategies for generating potent, long-lasting, functional immunity against multiple antigens. Implementation considerations in endemic areas will ultimately affect vaccine effectiveness, so innovations to simplify and enhance delivery are also needed. Whereas challenges remain, recent exciting progress and emerging knowledge promise hope for the future of malaria vaccines.",

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AU - Beeson, James G.

AU - Kurtovic, Liriye

AU - Dobaño, Carlota

AU - Opi, D. Herbert

AU - Chan, Jo Anne

AU - Feng, Gaoqian

AU - Good, Michael F.

AU - Reiling, Linda

AU - Boyle, Michelle J.

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AB - Although there has been major recent progress in malaria vaccine development, substantial challenges remain for achieving highly efficacious and durable vaccines against Plasmodium falciparum and Plasmodium vivax malaria. Greater knowledge of mechanisms and key targets of immunity are needed to accomplish this goal, together with new strategies for generating potent, long-lasting, functional immunity against multiple antigens. Implementation considerations in endemic areas will ultimately affect vaccine effectiveness, so innovations to simplify and enhance delivery are also needed. Whereas challenges remain, recent exciting progress and emerging knowledge promise hope for the future of malaria vaccines.

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Challenges and strategies for developing efficacious and long-lasting malaria vaccines

Abstract

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