Challenges and strategies for developing efficacious and long-lasting malaria vaccines

James G. Beeson, Liriye Kurtovic, Carlota Dobaño, D. Herbert Opi, Jo Anne Chan, Gaoqian Feng, Michael F. Good, Linda Reiling, Michelle J. Boyle

Research output: Contribution to journalArticlepeer-review


Although there has been major recent progress in malaria vaccine development, substantial challenges remain for achieving highly efficacious and durable vaccines against Plasmodium falciparum and Plasmodium vivax malaria. Greater knowledge of mechanisms and key targets of immunity are needed to accomplish this goal, together with new strategies for generating potent, long-lasting, functional immunity against multiple antigens. Implementation considerations in endemic areas will ultimately affect vaccine effectiveness, so innovations to simplify and enhance delivery are also needed. Whereas challenges remain, recent exciting progress and emerging knowledge promise hope for the future of malaria vaccines.

Original languageEnglish
Article numbereaau1458
Pages (from-to)1-17
Number of pages17
JournalScience Translational Medicine
Issue number474
Publication statusPublished - 9 Jan 2019


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