Abstract
Rationale and aim: Stroke survivors experience accelerated bone loss and increased fracture risk, particularly in paretic weight bearing limbs. Understanding how these changes unfold and their relationship to stroke severity and physical activity could help in the development of targeted interventions to prevent or reduce the severity of these outcomes. The primary aim of this study is to investigate the time course and magnitude of changes in volumetric bone mineral density within the first year after stroke, and to examine relationships with physical activity and motor recovery.
Design: This is a prospective, observational study of 43
nondiabetic, nonambulant adults with first ever hemispheric stroke.
Primary
outcome: The primary outcome was the difference in six-month change of
total volumetric bone mineral density between paretic and nonparetic distal
tibiae, measured at 7% of bone length site using high-resolution peripheral
quantitative computed tomography.
Secondary
outcomes: The secondary
outcomes are cortical and trabecular volumetric bone mineral density, cortical
thickness, and total and cross-sectional areas of distal tibiae and radii of
paretic and nonparetic limbs. Also included are total body and regional bone
mineral density derived using dual-energy X-ray absorptiometry, physical
activity measured using accelerometry, and motor recovery (Chedoke McMaster
Stroke Assessment).
Discussion: Measuring the timing and magnitude of changes to volumetric
bone mineral density and bone structure from immediately after stroke, and
relationships between these changes with physical activity and motor recovery
will provide the basis for targeted interventions to reduce fracture risk in
stroke survivors.
Original language | English |
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Pages (from-to) | 396-399 |
Number of pages | 4 |
Journal | International Journal of Stroke |
Volume | 10 |
Issue number | 3 |
DOIs |
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Publication status | Published - Apr 2015 |