Changing Ecotypes of Dengue Virus 2 Serotype in Nigeria and the Emergence of Cosmopolitan and Asian I Lineages, 1966–2019

Bernard A. Onoja; Mamoudou Maiga; Ridwan O. Adesola; Andrew M. Adamu; Oyelola A. Adegboye

doi:10.3390/vaccines11030547

Changing Ecotypes of Dengue Virus 2 Serotype in Nigeria and the Emergence of Cosmopolitan and Asian I Lineages, 1966–2019

Bernard A. Onoja, Mamoudou Maiga, Ridwan O. Adesola, Andrew M. Adamu, Oyelola A. Adegboye

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

98 Downloads (Pure)

Abstract

Dengue virus (DENV) is a leading mosquito-borne virus with a wide geographical spread and a major public health concern. DENV serotype 1 (DENV-1) and serotype 2 (DENV-2) were first reported in Africa in 1964 in Ibadan, Nigeria. Although the burden of dengue is unknown in many African countries, DENV-2 is responsible for major epidemics. In this study, we investigated the activities of DENV-2 to determine the circulating strains and to appraise the changing dynamics in the epidemiology of the virus in Nigeria. Nineteen DENV-2 sequences from 1966–2019 in Nigeria were retrieved from the GenBank of the National Center of Biotechnology Information (NCBI). A DENV genotyping tool was used to identify the specific genotypes. The evolutionary history procedure was performed on 54 DENV-2 sequences using MEGA 7. There is a deviation from Sylvatic DENV-2 to other genotypes in Nigeria. In 2019, the Asian I genotype of DENV-2 was predominant in southern Edo State, located in the tropical rainforest region, with the first report of the DENV-2 Cosmopolitan strain. We confirmed the circulation of other non-assigned genotypes of DENV-2 in Nigeria. Collectively, this shows that DENV-2 dynamics have changed from Sylvatic transmission reported in the 1960s with the identification of the Cosmopolitan strain and Asian lineages. Sustained surveillance, including vectorial studies, is required to fully establish the trend and determine the role of these vectors.

Original language	English
Article number	547
Journal	Vaccines
Volume	11
Issue number	3
DOIs	https://doi.org/10.3390/vaccines11030547
Publication status	Published - Mar 2023
Externally published	Yes

Bibliographical note

Funding Information:
We thank the University of Ibadan Medical Education Partnership Initiative Junior Faculty Project (UI-MEPI-J) for providing the support for this project. The content is solely the responsibility of the authors and does not represent the official views of the Fogarty International Centre of the National Institutes of Health.

Funding Information:
This work was supported by grant award number D43TW010140, from the Fogarty International Centre of the National Institutes of Health to B.A.O.

Publisher Copyright:
© 2023 by the authors.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/vaccines11030547

81396594-oaFinal published version, 2.84 MBLicence: CC BY

Cite this

@article{9aaa2043426146acacba15cf53e166d4,

title = "Changing Ecotypes of Dengue Virus 2 Serotype in Nigeria and the Emergence of Cosmopolitan and Asian I Lineages, 1966–2019",

abstract = "Dengue virus (DENV) is a leading mosquito-borne virus with a wide geographical spread and a major public health concern. DENV serotype 1 (DENV-1) and serotype 2 (DENV-2) were first reported in Africa in 1964 in Ibadan, Nigeria. Although the burden of dengue is unknown in many African countries, DENV-2 is responsible for major epidemics. In this study, we investigated the activities of DENV-2 to determine the circulating strains and to appraise the changing dynamics in the epidemiology of the virus in Nigeria. Nineteen DENV-2 sequences from 1966–2019 in Nigeria were retrieved from the GenBank of the National Center of Biotechnology Information (NCBI). A DENV genotyping tool was used to identify the specific genotypes. The evolutionary history procedure was performed on 54 DENV-2 sequences using MEGA 7. There is a deviation from Sylvatic DENV-2 to other genotypes in Nigeria. In 2019, the Asian I genotype of DENV-2 was predominant in southern Edo State, located in the tropical rainforest region, with the first report of the DENV-2 Cosmopolitan strain. We confirmed the circulation of other non-assigned genotypes of DENV-2 in Nigeria. Collectively, this shows that DENV-2 dynamics have changed from Sylvatic transmission reported in the 1960s with the identification of the Cosmopolitan strain and Asian lineages. Sustained surveillance, including vectorial studies, is required to fully establish the trend and determine the role of these vectors.",

keywords = "Asian I, cosmopolitan strain, dengue virus, ecotypes, Nigeria, sylvatic",

author = "Onoja, {Bernard A.} and Mamoudou Maiga and Adesola, {Ridwan O.} and Adamu, {Andrew M.} and Adegboye, {Oyelola A.}",

note = "Funding Information: We thank the University of Ibadan Medical Education Partnership Initiative Junior Faculty Project (UI-MEPI-J) for providing the support for this project. The content is solely the responsibility of the authors and does not represent the official views of the Fogarty International Centre of the National Institutes of Health. Funding Information: This work was supported by grant award number D43TW010140, from the Fogarty International Centre of the National Institutes of Health to B.A.O. Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = mar,

doi = "10.3390/vaccines11030547",

language = "English",

volume = "11",

journal = "Vaccines",

issn = "2076-393X",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "3",

}

TY - JOUR

T1 - Changing Ecotypes of Dengue Virus 2 Serotype in Nigeria and the Emergence of Cosmopolitan and Asian I Lineages, 1966–2019

AU - Onoja, Bernard A.

AU - Maiga, Mamoudou

AU - Adesola, Ridwan O.

AU - Adamu, Andrew M.

AU - Adegboye, Oyelola A.

N1 - Funding Information: We thank the University of Ibadan Medical Education Partnership Initiative Junior Faculty Project (UI-MEPI-J) for providing the support for this project. The content is solely the responsibility of the authors and does not represent the official views of the Fogarty International Centre of the National Institutes of Health. Funding Information: This work was supported by grant award number D43TW010140, from the Fogarty International Centre of the National Institutes of Health to B.A.O. Publisher Copyright: © 2023 by the authors.

PY - 2023/3

Y1 - 2023/3

N2 - Dengue virus (DENV) is a leading mosquito-borne virus with a wide geographical spread and a major public health concern. DENV serotype 1 (DENV-1) and serotype 2 (DENV-2) were first reported in Africa in 1964 in Ibadan, Nigeria. Although the burden of dengue is unknown in many African countries, DENV-2 is responsible for major epidemics. In this study, we investigated the activities of DENV-2 to determine the circulating strains and to appraise the changing dynamics in the epidemiology of the virus in Nigeria. Nineteen DENV-2 sequences from 1966–2019 in Nigeria were retrieved from the GenBank of the National Center of Biotechnology Information (NCBI). A DENV genotyping tool was used to identify the specific genotypes. The evolutionary history procedure was performed on 54 DENV-2 sequences using MEGA 7. There is a deviation from Sylvatic DENV-2 to other genotypes in Nigeria. In 2019, the Asian I genotype of DENV-2 was predominant in southern Edo State, located in the tropical rainforest region, with the first report of the DENV-2 Cosmopolitan strain. We confirmed the circulation of other non-assigned genotypes of DENV-2 in Nigeria. Collectively, this shows that DENV-2 dynamics have changed from Sylvatic transmission reported in the 1960s with the identification of the Cosmopolitan strain and Asian lineages. Sustained surveillance, including vectorial studies, is required to fully establish the trend and determine the role of these vectors.

AB - Dengue virus (DENV) is a leading mosquito-borne virus with a wide geographical spread and a major public health concern. DENV serotype 1 (DENV-1) and serotype 2 (DENV-2) were first reported in Africa in 1964 in Ibadan, Nigeria. Although the burden of dengue is unknown in many African countries, DENV-2 is responsible for major epidemics. In this study, we investigated the activities of DENV-2 to determine the circulating strains and to appraise the changing dynamics in the epidemiology of the virus in Nigeria. Nineteen DENV-2 sequences from 1966–2019 in Nigeria were retrieved from the GenBank of the National Center of Biotechnology Information (NCBI). A DENV genotyping tool was used to identify the specific genotypes. The evolutionary history procedure was performed on 54 DENV-2 sequences using MEGA 7. There is a deviation from Sylvatic DENV-2 to other genotypes in Nigeria. In 2019, the Asian I genotype of DENV-2 was predominant in southern Edo State, located in the tropical rainforest region, with the first report of the DENV-2 Cosmopolitan strain. We confirmed the circulation of other non-assigned genotypes of DENV-2 in Nigeria. Collectively, this shows that DENV-2 dynamics have changed from Sylvatic transmission reported in the 1960s with the identification of the Cosmopolitan strain and Asian lineages. Sustained surveillance, including vectorial studies, is required to fully establish the trend and determine the role of these vectors.

KW - Asian I

KW - cosmopolitan strain

KW - dengue virus

KW - ecotypes

KW - Nigeria

KW - sylvatic

UR - http://www.scopus.com/inward/record.url?scp=85152088547&partnerID=8YFLogxK

U2 - 10.3390/vaccines11030547

DO - 10.3390/vaccines11030547

M3 - Article

AN - SCOPUS:85152088547

SN - 2076-393X

VL - 11

JO - Vaccines

JF - Vaccines

IS - 3

M1 - 547

ER -

Changing Ecotypes of Dengue Virus 2 Serotype in Nigeria and the Emergence of Cosmopolitan and Asian I Lineages, 1966–2019

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this