Characterization of a novel thermostable nuclease homolog (NucM) in a highly divergent Staphylococcus aureus clade

Frieder Schaumburg; M Pauly; G Schubert; A Shittu; Steven Tong; Fabian Leendertz; Georg Peters; K Becker

doi:10.1128/JCM.02327-14

Characterization of a novel thermostable nuclease homolog (Nuc_M) in a highly divergent Staphylococcus aureus clade

Frieder Schaumburg, M Pauly, G Schubert, A Shittu, Steven Tong, Fabian Leendertz, Georg Peters, K Becker

Research output: Contribution to journal › Article

Abstract

A thermostable nuclease homologue (Nuc_M) in an animal-associated divergent clade of Staphylococcus aureus in sub-Saharan Africa has a highly divergent nucleotide sequence compared to those of the classical nuc1 and nuc2 genes of S. aureus. Its deduced amino acid sequences, tertiary structures, and nuclease activities, however, are similar.

Original language	English
Pages (from-to)	4036-4038
Number of pages	3
Journal	Journal of Clinical Microbiology
Volume	52
Issue number	11
DOIs	https://doi.org/10.1128/JCM.02327-14
Publication status	Published - Nov 2014

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Schaumburg, F., Pauly, M., Schubert, G., Shittu, A., Tong, S., Leendertz, F., ... Becker, K. (2014). Characterization of a novel thermostable nuclease homolog (Nuc_M) in a highly divergent Staphylococcus aureus clade. Journal of Clinical Microbiology, 52(11), 4036-4038. https://doi.org/10.1128/JCM.02327-14

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abstract = "A thermostable nuclease homologue (NucM) in an animal-associated divergent clade of Staphylococcus aureus in sub-Saharan Africa has a highly divergent nucleotide sequence compared to those of the classical nuc1 and nuc2 genes of S. aureus. Its deduced amino acid sequences, tertiary structures, and nuclease activities, however, are similar.",

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author = "Frieder Schaumburg and M Pauly and G Schubert and A Shittu and Steven Tong and Fabian Leendertz and Georg Peters and K Becker",

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AU - Schaumburg, Frieder

AU - Pauly, M

AU - Schubert, G

AU - Shittu, A

AU - Tong, Steven

AU - Leendertz, Fabian

AU - Peters, Georg

AU - Becker, K

PY - 2014/11

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AB - A thermostable nuclease homologue (NucM) in an animal-associated divergent clade of Staphylococcus aureus in sub-Saharan Africa has a highly divergent nucleotide sequence compared to those of the classical nuc1 and nuc2 genes of S. aureus. Its deduced amino acid sequences, tertiary structures, and nuclease activities, however, are similar.

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KW - thermostable nuclease

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KW - controlled study

KW - enzyme activity

KW - enzyme analysis

KW - enzyme conformation

KW - enzyme stability

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KW - genetic variability

KW - nonhuman

KW - nuc gene

KW - nuc1 gene

KW - nuc2 gene

KW - nucleotide sequence

KW - polymerase chain reaction

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10.1128/JCM.02327-14