Childhood adversity, allostatic load, and adult mental health: Study protocol using the Avon Longitudinal Study of Parents and Children birth cohort

Sabine Finlay; Robert Paul Juster; Oyelola Adegboye; Donna Rudd; Brett McDermott; Zoltán Sarnyai

doi:10.3389/fpsyt.2022.976140

Childhood adversity, allostatic load, and adult mental health: Study protocol using the Avon Longitudinal Study of Parents and Children birth cohort

Sabine Finlay, Robert Paul Juster, Oyelola Adegboye, Donna Rudd, Brett McDermott, Zoltán Sarnyai

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Abstract

Introduction: The cumulative burden of chronic stress and life events has been termed allostatic load. Elevated allostatic load indices are associated with different mental health conditions in adulthood. To date, however, the association between elevated allostatic load in childhood and later development of mental health conditions has not been investigated. Methods: Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we will calculate allostatic load indices using biomarkers representing the cardiovascular, metabolic, immune, and neuroendocrine systems, at the ages of 9 and 17 years. Bivariate and multivariable logistic regression models will be used to investigate the association between allostatic load and psychiatric disorders in adulthood. Furthermore, the role of adverse childhood experiences as a modifier will be investigated. Discussion: This protocol describes a strategy for investigating the association between elevated allostatic load indices in childhood at the age of 9 years old and psychiatric disorders in adulthood at 24 years old.

Original language	English
Article number	976140
Journal	Frontiers in Psychiatry
Volume	13
DOIs	https://doi.org/10.3389/fpsyt.2022.976140
Publication status	Published - 5 Jan 2023
Externally published	Yes

Bibliographical note

Funding Information:
The UK Medical Research Council and Wellcome (Grant Ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and SF will serve as guarantor for the contents of this paper. A comprehensive list of grant funding is available on the ALSPAC website ( http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf ). This research was specifically funded by Wellcome Trust and MRC (core) (Grant Ref: 076467/Z/05/Z), British Heart Foundation (Grant Ref: CS/15/6/31468), NIH (Grant Ref: PD301198-SC101645), and MRC (Grant Ref: MR/M006727/1). This work was funded as a whole by the Australian Institute of Medical Scientists (Grant Ref: REGS-29277-2021).

Publisher Copyright:
Copyright © 2023 Finlay, Juster, Adegboye, Rudd, McDermott and Sarnyai.

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10.3389/fpsyt.2022.976140

81397633Final published version, 429 KBLicence: CC BY

Cite this

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title = "Childhood adversity, allostatic load, and adult mental health: Study protocol using the Avon Longitudinal Study of Parents and Children birth cohort",

abstract = "Introduction: The cumulative burden of chronic stress and life events has been termed allostatic load. Elevated allostatic load indices are associated with different mental health conditions in adulthood. To date, however, the association between elevated allostatic load in childhood and later development of mental health conditions has not been investigated. Methods: Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we will calculate allostatic load indices using biomarkers representing the cardiovascular, metabolic, immune, and neuroendocrine systems, at the ages of 9 and 17 years. Bivariate and multivariable logistic regression models will be used to investigate the association between allostatic load and psychiatric disorders in adulthood. Furthermore, the role of adverse childhood experiences as a modifier will be investigated. Discussion: This protocol describes a strategy for investigating the association between elevated allostatic load indices in childhood at the age of 9 years old and psychiatric disorders in adulthood at 24 years old.",

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note = "Funding Information: The UK Medical Research Council and Wellcome (Grant Ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and SF will serve as guarantor for the contents of this paper. A comprehensive list of grant funding is available on the ALSPAC website ( http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf ). This research was specifically funded by Wellcome Trust and MRC (core) (Grant Ref: 076467/Z/05/Z), British Heart Foundation (Grant Ref: CS/15/6/31468), NIH (Grant Ref: PD301198-SC101645), and MRC (Grant Ref: MR/M006727/1). This work was funded as a whole by the Australian Institute of Medical Scientists (Grant Ref: REGS-29277-2021). Publisher Copyright: Copyright {\textcopyright} 2023 Finlay, Juster, Adegboye, Rudd, McDermott and Sarnyai.",

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AU - McDermott, Brett

AU - Sarnyai, Zoltán

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N2 - Introduction: The cumulative burden of chronic stress and life events has been termed allostatic load. Elevated allostatic load indices are associated with different mental health conditions in adulthood. To date, however, the association between elevated allostatic load in childhood and later development of mental health conditions has not been investigated. Methods: Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we will calculate allostatic load indices using biomarkers representing the cardiovascular, metabolic, immune, and neuroendocrine systems, at the ages of 9 and 17 years. Bivariate and multivariable logistic regression models will be used to investigate the association between allostatic load and psychiatric disorders in adulthood. Furthermore, the role of adverse childhood experiences as a modifier will be investigated. Discussion: This protocol describes a strategy for investigating the association between elevated allostatic load indices in childhood at the age of 9 years old and psychiatric disorders in adulthood at 24 years old.

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Childhood adversity, allostatic load, and adult mental health: Study protocol using the Avon Longitudinal Study of Parents and Children birth cohort

Abstract

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