Chloroquine and hydroxychloroquine

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Citations (Scopus)

Abstract

Chloroquine (CQ; 7-chloro-4[4-diethylamino-1-methlybutylamino]) is a 4-aminoquinoline derivative that has been used extensively for the treatment and prevention of malaria. First synthesized in 1934 by H. Anderson in the Bayer Laboratory in Elberfeld, Germany, it was given the name Resochin and tested against avian malaria and subsequently against human Plasmodium vivax in psychiatric patients in Dusseldorf (Coates, 1963). Despite demonstrated anti-malarial efficacy, it was apparently abandoned after being found “too toxic for practical use in humans.” The compound was rediscovered in the early 1940s through militarily motivated anti-malarial drug research, and in 1946 it was given the name chloroquine and became the drug of choice for malaria worldwide. Although CQ remains effective for non-falciparum malaria in many parts of the world, its use is limited by widespread resistance in Plasmodium falciparum and increasing resistance in P. vivax.

Original languageEnglish
Title of host publicationKucers' The Use of Antibiotics
Subtitle of host publicationA Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition
PublisherCRC Press
Chapter175
Pages3030-3048
Number of pages19
Volume3
Edition7th
ISBN (Electronic)9781498747967
ISBN (Print)9781498747950
DOIs
Publication statusPublished - 1 Jan 2017

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