Chloroquine and hydroxychloroquine

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Chloroquine (CQ; 7-chloro-4[4-diethylamino-1-methlybutylamino]) is a 4-aminoquinoline derivative that has been used extensively for the treatment and prevention of malaria. First synthesized in 1934 by H. Anderson in the Bayer Laboratory in Elberfeld, Germany, it was given the name Resochin and tested against avian malaria and subsequently against human Plasmodium vivax in psychiatric patients in Dusseldorf (Coates, 1963). Despite demonstrated anti-malarial efficacy, it was apparently abandoned after being found “too toxic for practical use in humans.” The compound was rediscovered in the early 1940s through militarily motivated anti-malarial drug research, and in 1946 it was given the name chloroquine and became the drug of choice for malaria worldwide. Although CQ remains effective for non-falciparum malaria in many parts of the world, its use is limited by widespread resistance in Plasmodium falciparum and increasing resistance in P. vivax.

    Original languageEnglish
    Title of host publicationKucers the Use of Antibiotics
    Subtitle of host publicationA Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition
    PublisherCRC Press
    Chapter175
    Pages3030-3048
    Number of pages19
    Volume3
    Edition7th
    ISBN (Electronic)9781498747967
    ISBN (Print)9781498747950
    DOIs
    Publication statusPublished - 1 Jan 2017

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  • Cite this

    Barber, B. E. (2017). Chloroquine and hydroxychloroquine. In Kucers the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition (7th ed., Vol. 3, pp. 3030-3048). CRC Press. https://doi.org/10.1201/9781498747967