Abstract
Background: Acute bronchiolitis is common in young children, and some children develop chronic cough after their bronchiolitis. We thus undertook systematic reviews based on key questions (KQs) using the PICO (Population, Intervention, Comparison, Outcome) format. The KQs were: Among children with chronic cough (> 4 weeks) after acute viral bronchiolitis, how effective are the following interventions in improving the resolution of cough?: (1) Antibiotics. If so what type and for how long? (2) Asthma medications (inhaled steroids, beta2 agonist, montelukast); and (3) Inhaled osmotic agents like hypertonic saline?
Methods: We used the CHEST expert cough panel’s protocol and the American College of Chest Physicians (CHEST) methodological guidelines and GRADE framework. Data from the systematic reviews in conjunction with patients’ values and preferences and the clinical context were used to form these suggestions. Delphi methodology was used to obtain consensus.
Results: Several studies and systematic reviews on the efficacy of the three types of interventions listed in the introduction were found but no data were relevant to our KQs. Thus, no recommendations on using the interventions above could be formulated.
Conclusions: The panel made several consensus-based suggestions and identified directions for future studies to advance the field of managing chronic cough post-acute bronchiolitis in children.
| Original language | English |
|---|---|
| Pages (from-to) | 378-382 |
| Number of pages | 5 |
| Journal | Chest |
| Volume | 154 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 Aug 2018 |
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Chronic cough related to acute viral bronchiolitis in children : CHEST Expert Panel Report. / CHEST Expert Cough Panel.
In: Chest, Vol. 154, No. 2, 01.08.2018, p. 378-382.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Chronic cough related to acute viral bronchiolitis in children
T2 - CHEST Expert Panel Report
AU - CHEST Expert Cough Panel
AU - Chang, Anne B.
AU - Oppenheimer, John
AU - Rubin, Bruce K.
AU - Weinberger, Miles
AU - Irwin, Richard S.
AU - Adams, Todd M.
AU - Altman, Kenneth W.
AU - Azoulay, Elie
AU - Barker, Alan F.
AU - Birring, Surinder S.
AU - Blackhall, Fiona
AU - Bolser, Donald C.
AU - Boulet, Louis Philippe
AU - Braman, Sidney S.
AU - Brightling, Christopher
AU - Callahan-Lyon, Priscilla
AU - Chang, Anne B.
AU - Cowley, Terrie
AU - Davenport, Paul
AU - Ebihara, Satoru
AU - El Solh, Ali A.
AU - Escalante, Patricio
AU - Field, Stephen K.
AU - Fisher, Dina
AU - French, Cynthia T.
AU - Gibson, Peter
AU - Gold, Philip
AU - Harding, Susan M.
AU - Harnden, Anthony
AU - Hill, Adam T.
AU - Irwin, Richard S.
AU - Kahrilas, Peter J.
AU - Kavanagh, Joanne
AU - Keogh, Karina A.
AU - Lai, Kefang
AU - Lane, Andrew P.
AU - Lim, Kaiser
AU - Madison, J. Mark
AU - Malesker, Mark A.
AU - Mazzone, Stuart
AU - McGarvey, Lorcan
AU - Metlay, Joshua P.
AU - Molasoitis, Alex
AU - Moore, Abigail
AU - Murad, M. Hassan
AU - Narasimhan, Mangala
AU - Nguyen, Huong Q.
AU - Newcombe, Peter
AU - Oppenheimer, John
AU - Restrepo, Marcos I.
AU - Rosen, Mark
AU - Rubin, Bruce
AU - Ryu, Jay H.
AU - Singh, Sonal
AU - Smith, Maeve P.
AU - Tarlo, Susan M.
AU - Turmel, Julie
AU - Vertigan, Anne E.
AU - Wang, Gang
AU - Weinberger, Miles
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Background: Acute bronchiolitis is common in young children, and some children develop chronic cough after their bronchiolitis. We thus undertook systematic reviews based on key questions (KQs) using the PICO (Population, Intervention, Comparison, Outcome) format. The KQs were: Among children with chronic cough (> 4 weeks) after acute viral bronchiolitis, how effective are the following interventions in improving the resolution of cough?: (1) Antibiotics. If so what type and for how long? (2) Asthma medications (inhaled steroids, beta2 agonist, montelukast); and (3) Inhaled osmotic agents like hypertonic saline?Methods: We used the CHEST expert cough panel’s protocol and the American College of Chest Physicians (CHEST) methodological guidelines and GRADE framework. Data from the systematic reviews in conjunction with patients’ values and preferences and the clinical context were used to form these suggestions. Delphi methodology was used to obtain consensus.Results: Several studies and systematic reviews on the efficacy of the three types of interventions listed in the introduction were found but no data were relevant to our KQs. Thus, no recommendations on using the interventions above could be formulated.Conclusions: The panel made several consensus-based suggestions and identified directions for future studies to advance the field of managing chronic cough post-acute bronchiolitis in children.
AB - Background: Acute bronchiolitis is common in young children, and some children develop chronic cough after their bronchiolitis. We thus undertook systematic reviews based on key questions (KQs) using the PICO (Population, Intervention, Comparison, Outcome) format. The KQs were: Among children with chronic cough (> 4 weeks) after acute viral bronchiolitis, how effective are the following interventions in improving the resolution of cough?: (1) Antibiotics. If so what type and for how long? (2) Asthma medications (inhaled steroids, beta2 agonist, montelukast); and (3) Inhaled osmotic agents like hypertonic saline?Methods: We used the CHEST expert cough panel’s protocol and the American College of Chest Physicians (CHEST) methodological guidelines and GRADE framework. Data from the systematic reviews in conjunction with patients’ values and preferences and the clinical context were used to form these suggestions. Delphi methodology was used to obtain consensus.Results: Several studies and systematic reviews on the efficacy of the three types of interventions listed in the introduction were found but no data were relevant to our KQs. Thus, no recommendations on using the interventions above could be formulated.Conclusions: The panel made several consensus-based suggestions and identified directions for future studies to advance the field of managing chronic cough post-acute bronchiolitis in children.
KW - cough
KW - evidence-based medicine
KW - guidelines
UR - http://www.scopus.com/inward/record.url?scp=85049298787&partnerID=8YFLogxK
U2 - 10.1016/j.chest.2018.04.019
DO - 10.1016/j.chest.2018.04.019
M3 - Article
VL - 154
SP - 378
EP - 382
JO - Chest
JF - Chest
SN - 0012-3692
IS - 2
ER -