Chronic melioidosis, relapse and latency

Direk Limmathurotsakul, Gavin C.K.W Koh, Sharon J Peacock, Bart Currie

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Chronic melioidosis is the presence of symptoms for two or more months prior to presentation, and may mimic many diseases, including tuberculosis and cancer. Latent melioidosis is a retrospective term used to describe individuals who develop clinical features of infection many months or years after exposure to Burkholderia pseudomallei and presumed infection. There is usually no recollection of a febrile illness around the time of exposure in these cases, and the onset of clinical melioidosis is often associated with a deteriorating host immune response. Recurrentmelioidosis is the development of a further episode of B. pseudomallei infection and is due to relapse following failure to eradicate the organism, or re-infection with a new B. pseudomallei strain. Risk factors for relapse include short duration and choice of antimicrobial therapy for the primary infection; no risk factors have been identified for re-infection other than re-exposure to B. pseudomallei. Understanding specific risk factors for relapse and re-infection could result in better preventive strategies.
    Original languageEnglish
    Title of host publicationMelioidosis
    Subtitle of host publicationA Century of Observation and Research
    EditorsNatkunan Ketheesan
    PublisherElsevier
    ChapterSection IV.2
    Pages120-129
    Number of pages10
    ISBN (Electronic)9780444534798
    Publication statusPublished - 2012

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  • Cite this

    Limmathurotsakul, D., Koh, G. C. K. W., Peacock, S. J., & Currie, B. (2012). Chronic melioidosis, relapse and latency. In N. Ketheesan (Ed.), Melioidosis: A Century of Observation and Research (pp. 120-129). Elsevier.