Climate change alters global food systems, especially agriculture and fisheries—significant aspects of the livelihoods and food security of populations. The 2014 IPCC Fifth Assessment Report identified Southeast Asia as the most vulnerable coastal region in the world, and highlighted the potential distribution of impacts and risks of climate change in the region. While climate hazards may differ across geographical regions, the impact of climate extremes on food production will affect marginal farmers, fishers and poor urban consumers disproportionately, as they have limited capacities to adapt to and recover from extreme weather events. Governments and other stakeholders need to respond to climate extremes and incorporate adaptation into national development plans. Unfortunately, there is still limited peer-review publication on the subject matter. This paper presents some findings from research on observed and projected loss and damage inflicted by climate extremes on agricultural crops in Southeast Asia.