Clinical utility of exhaled nitric oxide fraction in the management of asthma and COPD

Steve W. Turner, Anne B. Chang, Ian A. Yang

    Research output: Contribution to journalReview article

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    Abstract

    Exhaled nitric oxide fraction (FENO) values can be easily measured using portable analysers and are a surrogate marker of airway eosinophilia. FENO may be useful in diagnosing and monitoring conditions characterised by airway eosinophilia, i.e. asthma and possibly COPD. Many factors other than asthma and COPD affect FENO, especially atopy, which is associated with elevated FENO. One guideline recommends that FENO should be used as part of the diagnostic pathway for asthma diagnosis in adults and children aged >5 years. The role of FENO in monitoring asthma is even less clear, and most guidelines do not recommend its use outside of specialist asthma clinics. Currently, FENO is not recommended for diagnosis or monitoring of COPD. Although FENO is starting to find a place in the management of asthma in children and adults, considerably more research is required before the potential of FENO as an objective measurement in asthma and COPD can be realised.

    Original languageEnglish
    Pages (from-to)306-316
    Number of pages11
    JournalBreathe
    Volume15
    Issue number4
    DOIs
    Publication statusPublished - 1 Dec 2019

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