This is a commentary on a Cochrane review, published in the issue of EBCH, first published as: Marchant JM, Morris PS, Gaffney J, Chang AB. Antibiotics for prolonged moist cough in children. Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD004822. DOI: 10.1002/14651858.CD004822.pub2. Further information for this Cochrane review is available in this issue of EBCH in the accompanying Summary article.