Community-associated Methicillin-resistant Staphylococcus aureus Skin Infections in the Tropics

Steven Tong, Andrew Steer, Adam Jenney, Jonathan Carapetis

    Research output: Contribution to journalComment/debate

    Abstract

    Skin and soft tissue infections (SSTI) caused by Staphylococcus aureus are very common, particularly in children, in tropical regions. The proportion of S aureus SSTI caused by community-associated methicillin-resistant S aureus (CA-MRSA) varies according to region, but is up to 25% in some areas. There are diverse CA-MRSA clones, including several that harbor Panton-Valentine leukocidin. Key predisposing factors for staphylococcal infections are scabies infestation, overcrowding, poor hygiene, and inadequate water supplies. In the setting of a community outbreak of staphylococcal SSTI, interventions intended to improve personal and community hygiene are likely to be the most practical, effective, and achievable. Options for oral treatment of clinical infections caused by CA-MRSA include clindamycin and trimethoprim-sulfamethoxazole. Although rapid diagnostics are now available, and 2 vaccines have reached clinical trials, neither of these is likely to be of use in tropical, developing regions in the near future. � 2011.
    Original languageEnglish
    Pages (from-to)21-32
    Number of pages12
    JournalDermatologic Clinics
    Volume29
    Issue number1
    DOIs
    Publication statusPublished - Jan 2011

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