Comorbid Heart Failure and Renal Impairment: Epidemiology and Management

Pupalan Iyngkaran, Merlin Thomas, Sandawana William Majoni, Nagesh S. Anavekar, Claudio Ronco

Research output: Contribution to journalReview articlepeer-review


Heart failure mortality is significantly increased in patients with baseline renal impairment and those with underlying heart failure who subsequently develop renal dysfunction. This accelerated progression occurs independent of the cause or grade of renal dysfunction and baseline risk factors. Recent large prospective databases have highlighted the depth of the current problem, while longitudinal population studies support an increasing disease burden. We have extensively reviewed the epidemiological and therapeutic data among these patients. The evidence points to a progression of heart failure early in renal impairment, even in the albuminuric stage. The data also support poor prescription of prognostic therapies. As renal function is the most important prognostic factor in heart failure, it is important to establish the current understanding of the disease burden and the therapeutic implications.
Original languageEnglish
Pages (from-to)281-297
Number of pages17
JournalCardiorenal Medicine
Issue number4
Publication statusPublished - 2012
Externally publishedYes


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