Comparative Accuracy of the InBios Scrub Typhus Detect IgM Rapid Test for the Detection of IgM Antibodies by Using Conventional Serology

Hugh William Fluellen Kingston, Stuart D. Blacksell, Ampai Tanganuchitcharnchai, Achara Laongnualpanich, Buddha Basnyat, Nicholas Day, Daniel H Paris

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    Abstract

    This study investigated the comparative accuracy of a recombinant 56-kDa type-specific antigen-based rapid diagnostic test (RDT) for scrub typhus for the detection of IgM antibodies by using conventional serology in well-characterized serum samples from undifferentiated febrile illness patients. The RDT showed high specificity and promising comparative accuracy, with 82% sensitivity and 98% specificity for samples defined positive at an IgM indirect immunofluorescence assay positivity cutoff titer of ≥1:1,600 versus 92% and 95% at ≥1:6,400, respectively.
    Original languageEnglish
    Pages (from-to)1130-1132
    Number of pages3
    JournalClinical and Vaccine Immunology
    Volume22
    Issue number10
    DOIs
    Publication statusPublished - 2015

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