Comparison of Rapid Diagnostic Tests for the Detection of Plasmodium vivax Malaria in South Korea

Jung-Yeon Kim, So-Young Ji, Youn-Kyoung Goo, Byoung-Kuk Na, Hyo-Joo Pyo, Han-Na Lee, Juyoung Lee, Nam Hee Kim, Lorenz Von Seidlein, Q Cheng, Shin-Hyung Cho, Won-Ja Lee

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Abstract

South Korea is one of many countries with endemic Plasmodium vivax malaria. Here we report the evaluation of four rapid diagnostic tests (RDTs) for diagnosis of this disease. A total of 253 subjects were enrolled in the study. The sensitivities, specificities and agreement frequencies were estimated by comparing the four RDTs against the standard of nested-PCR and microscopic examination. The CareStartTM and SD Bioline had higher test sensitivities (99.4 and 98.8%, respectively) compared with the NanoSign and Asan Easy tests (93.0 and 94.7%, respectively). The CareStartTM and SD Bioline tests could detect P. vivax in samples with parasite densities <150/?l, which was a slightly better performance than the other two RDTs. The quantitative accuracy of the four RDTs was also estimated by comparing results with P. vivax counts from blood samples. Lower test price would result in increased use of these RDTs in the field. The results of this study contribute valuable information that will aid in the selection of a diagnostic method for the detection of malaria. � 2013 Kim et al.
Original languageEnglish
Article numbere64353
Pages (from-to)1-6
Number of pages6
JournalPLoS One
Volume8
Issue number5
DOIs
Publication statusPublished - 7 May 2013

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