@article{e2b9abac37f84ecd8ae46244fc30a2a0,
title = "Conservation of resistance-nodulation-cell division efflux pump-mediated antibiotic resistance in Burkholderia cepacia complex and Burkholderia pseudomallei complex species",
abstract = "Burkholderia cepacia complex (Bcc) and Burkholderia pseudomallei complex (Bpc) species include pathogens that are typically multidrug resistant. Dominant intrinsic and acquired multidrug resistance mechanisms are efflux mediated by pumps of the resistance-nodulation-cell division (RND) family. From comparative bioinformatic and, in many instances, functional studies, we infer that RND pump-based resistance mechanisms are conserved in Burkholderia. We propose to use these findings as a foundation for adoption of a uniform RND efflux pump nomenclature. ",
keywords = "Burkholderia, Multidrug resistance, RND efflux pumps",
author = "Nawarat Somprasong and Jinhee Yi and Hall, {Carina M.} and Webb, {Jessica R.} and Sahl, {Jason W.} and Wagner, {David M.} and Paul Keim and Currie, {Bart J.} and Schweizer, {Herbert P.}",
note = "Funding Information: This work was funded by grant HDTRA1-17-1005-1 from the United States Defense Threat Reduction Agency (DTRA). The contents are solely the responsibility of the authors and do not necessarily represent the official views of DTRA or the Department of Defense. We acknowledge John J. LiPuma, Director, Burkholderia cepacia Research Laboratory & Repository, University of Michigan, for his insightful comments on the manuscript. Publisher Copyright: {\textcopyright} 2021 American Society for Microbiology. All Rights Reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = sep,
doi = "10.1128/AAC.00920-21",
language = "English",
volume = "65",
pages = "1--7",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "9",
}