Conservation of resistance-nodulation-cell division efflux pump-mediated antibiotic resistance in burkholderia cepacia complex and burkholderia pseudomallei complex species

Nawarat Somprasong, Jinhee Yi, Carina M. Hall, Jessica R. Webb, Jason W. Sahl, David M. Wagner, Paul Keim, Bart J. Currie, Herbert P. Schweizer

Research output: Contribution to journalArticlepeer-review

Abstract

Burkholderia cepacia complex (Bcc) and Burkholderia pseudomallei complex (Bpc) species include pathogens that are typically multidrug resistant. Dominant intrinsic and acquired multidrug resistance mechanisms are efflux mediated by pumps of the resistance-nodulation-cell division (RND) family. From comparative bioinformatic and, in many instances, functional studies, we infer that RND pump-based resistance mechanisms are conserved in Burkholderia. We propose to use these findings as a foundation for adoption of a uniform RND efflux pump nomenclature.

Original languageEnglish
Article numbere00920-21
Pages (from-to)1-7
Number of pages7
JournalAntimicrobial Agents and Chemotherapy
Volume65
Issue number9
Early online dateAug 2021
DOIs
Publication statusPublished - Sep 2021

Fingerprint

Dive into the research topics of 'Conservation of resistance-nodulation-cell division efflux pump-mediated antibiotic resistance in burkholderia cepacia complex and burkholderia pseudomallei complex species'. Together they form a unique fingerprint.

Cite this