Conservation of resistance-nodulation-cell division efflux pump-mediated antibiotic resistance in Burkholderia cepacia complex and Burkholderia pseudomallei complex species

Nawarat Somprasong; Jinhee Yi; Carina M. Hall; Jessica R. Webb; Jason W. Sahl; David M. Wagner; Paul Keim; Bart J. Currie; Herbert P. Schweizer

doi:10.1128/AAC.00920-21

Conservation of resistance-nodulation-cell division efflux pump-mediated antibiotic resistance in Burkholderia cepacia complex and Burkholderia pseudomallei complex species

Nawarat Somprasong, Jinhee Yi, Carina M. Hall, Jessica R. Webb, Jason W. Sahl, David M. Wagner, Paul Keim, Bart J. Currie, Herbert P. Schweizer

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Burkholderia cepacia complex (Bcc) and Burkholderia pseudomallei complex (Bpc) species include pathogens that are typically multidrug resistant. Dominant intrinsic and acquired multidrug resistance mechanisms are efflux mediated by pumps of the resistance-nodulation-cell division (RND) family. From comparative bioinformatic and, in many instances, functional studies, we infer that RND pump-based resistance mechanisms are conserved in Burkholderia. We propose to use these findings as a foundation for adoption of a uniform RND efflux pump nomenclature.

Original language	English
Article number	e00920-21
Pages (from-to)	1-7
Number of pages	7
Journal	Antimicrobial Agents and Chemotherapy
Volume	65
Issue number	9
Early online date	Aug 2021
DOIs	https://doi.org/10.1128/AAC.00920-21
Publication status	Published - Sept 2021

Bibliographical note

Funding Information:
This work was funded by grant HDTRA1-17-1005-1 from the United States Defense Threat Reduction Agency (DTRA). The contents are solely the responsibility of the authors and do not necessarily represent the official views of DTRA or the Department of Defense. We acknowledge John J. LiPuma, Director, Burkholderia cepacia Research Laboratory & Repository, University of Michigan, for his insightful comments on the manuscript.

Publisher Copyright:
© 2021 American Society for Microbiology. All Rights Reserved.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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10.1128/AAC.00920-21

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Somprasong, N., Yi, J., Hall, C. M., Webb, J. R., Sahl, J. W., Wagner, D. M., Keim, P., Currie, B. J., & Schweizer, H. P. (2021). Conservation of resistance-nodulation-cell division efflux pump-mediated antibiotic resistance in Burkholderia cepacia complex and Burkholderia pseudomallei complex species. Antimicrobial Agents and Chemotherapy, 65(9), 1-7. Article e00920-21. https://doi.org/10.1128/AAC.00920-21

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title = "Conservation of resistance-nodulation-cell division efflux pump-mediated antibiotic resistance in Burkholderia cepacia complex and Burkholderia pseudomallei complex species",

abstract = "Burkholderia cepacia complex (Bcc) and Burkholderia pseudomallei complex (Bpc) species include pathogens that are typically multidrug resistant. Dominant intrinsic and acquired multidrug resistance mechanisms are efflux mediated by pumps of the resistance-nodulation-cell division (RND) family. From comparative bioinformatic and, in many instances, functional studies, we infer that RND pump-based resistance mechanisms are conserved in Burkholderia. We propose to use these findings as a foundation for adoption of a uniform RND efflux pump nomenclature. ",

keywords = "Burkholderia, Multidrug resistance, RND efflux pumps",

author = "Nawarat Somprasong and Jinhee Yi and Hall, \{Carina M.\} and Webb, \{Jessica R.\} and Sahl, \{Jason W.\} and Wagner, \{David M.\} and Paul Keim and Currie, \{Bart J.\} and Schweizer, \{Herbert P.\}",

note = "Funding Information: This work was funded by grant HDTRA1-17-1005-1 from the United States Defense Threat Reduction Agency (DTRA). The contents are solely the responsibility of the authors and do not necessarily represent the official views of DTRA or the Department of Defense. We acknowledge John J. LiPuma, Director, Burkholderia cepacia Research Laboratory \& Repository, University of Michigan, for his insightful comments on the manuscript. Publisher Copyright: {\textcopyright} 2021 American Society for Microbiology. All Rights Reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

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doi = "10.1128/AAC.00920-21",

language = "English",

volume = "65",

pages = "1--7",

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Somprasong, N, Yi, J, Hall, CM, Webb, JR, Sahl, JW, Wagner, DM, Keim, P, Currie, BJ & Schweizer, HP 2021, 'Conservation of resistance-nodulation-cell division efflux pump-mediated antibiotic resistance in Burkholderia cepacia complex and Burkholderia pseudomallei complex species', Antimicrobial Agents and Chemotherapy, vol. 65, no. 9, e00920-21, pp. 1-7. https://doi.org/10.1128/AAC.00920-21

Conservation of resistance-nodulation-cell division efflux pump-mediated antibiotic resistance in Burkholderia cepacia complex and Burkholderia pseudomallei complex species. / Somprasong, Nawarat; Yi, Jinhee; Hall, Carina M. et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 65, No. 9, e00920-21, 09.2021, p. 1-7.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Conservation of resistance-nodulation-cell division efflux pump-mediated antibiotic resistance in Burkholderia cepacia complex and Burkholderia pseudomallei complex species

AU - Somprasong, Nawarat

AU - Yi, Jinhee

AU - Hall, Carina M.

AU - Webb, Jessica R.

AU - Sahl, Jason W.

AU - Wagner, David M.

AU - Keim, Paul

AU - Currie, Bart J.

AU - Schweizer, Herbert P.

N1 - Funding Information: This work was funded by grant HDTRA1-17-1005-1 from the United States Defense Threat Reduction Agency (DTRA). The contents are solely the responsibility of the authors and do not necessarily represent the official views of DTRA or the Department of Defense. We acknowledge John J. LiPuma, Director, Burkholderia cepacia Research Laboratory & Repository, University of Michigan, for his insightful comments on the manuscript. Publisher Copyright: © 2021 American Society for Microbiology. All Rights Reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/9

Y1 - 2021/9

N2 - Burkholderia cepacia complex (Bcc) and Burkholderia pseudomallei complex (Bpc) species include pathogens that are typically multidrug resistant. Dominant intrinsic and acquired multidrug resistance mechanisms are efflux mediated by pumps of the resistance-nodulation-cell division (RND) family. From comparative bioinformatic and, in many instances, functional studies, we infer that RND pump-based resistance mechanisms are conserved in Burkholderia. We propose to use these findings as a foundation for adoption of a uniform RND efflux pump nomenclature.

AB - Burkholderia cepacia complex (Bcc) and Burkholderia pseudomallei complex (Bpc) species include pathogens that are typically multidrug resistant. Dominant intrinsic and acquired multidrug resistance mechanisms are efflux mediated by pumps of the resistance-nodulation-cell division (RND) family. From comparative bioinformatic and, in many instances, functional studies, we infer that RND pump-based resistance mechanisms are conserved in Burkholderia. We propose to use these findings as a foundation for adoption of a uniform RND efflux pump nomenclature.

KW - Burkholderia

KW - Multidrug resistance

KW - RND efflux pumps

UR - https://www.scopus.com/pages/publications/85112824623

U2 - 10.1128/AAC.00920-21

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AN - SCOPUS:85112824623

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 9

M1 - e00920-21

ER -

Conservation of resistance-nodulation-cell division efflux pump-mediated antibiotic resistance in Burkholderia cepacia complex and Burkholderia pseudomallei complex species

Abstract

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