Contemporary management of bronchiectasis in children

Johnny Wu, Anne B. Chang, Danielle F. Wurzel

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Introduction: Bronchiectasis is increasingly recognized as a major cause of morbidity and mortality worldwide. It affects children of all ethnicities and socioeconomic backgrounds and represents a far greater burden than cystic fibrosis (CF). Bronchiectasis often begins in childhood and the radiological changes can be reversed, when mild, with optimal management. As there are limited pediatric studies in this field, current treatment approaches in children are based largely upon adult and/or CF studies. The recent establishment of bronchiectasis registries will improve understanding of pediatric bronchiectasis and increase capacity for large-scale research studies in the future.

Areas covered: This review summarizes the current management of bronchiectasis in children and highlights important knowledge gaps and areas for future research. Current treatment approaches are based largely on consensus guidelines from international experts in the field. Studies were identified through searching Medline via the Ovid interface and Pubmed using the search terms ‘bronchiectasis’ and ‘children’ or ‘pediatric’ and ‘management’ or ‘treatments’.

Expert opinion: Bronchiectasis is heterogeneous in nature and a one-size-fits-all approach has limitations. Future research should focus on advancing our understanding of the aetiopathogenesis of bronchiectasis. This approach will facilitate development of targetted therapeutic interventions to slow, halt or even reverse bronchiectasis in childhood.

Original languageEnglish
Pages (from-to)969-979
Number of pages11
JournalExpert Review of Respiratory Medicine
Volume13
Issue number10
DOIs
Publication statusE-pub ahead of print - 27 Aug 2019

Fingerprint

Bronchiectasis
Pediatrics
Cystic Fibrosis
Expert Testimony
Therapeutics
PubMed
Registries
Guidelines
Morbidity
Mortality

Cite this

Wu, Johnny ; Chang, Anne B. ; Wurzel, Danielle F. / Contemporary management of bronchiectasis in children. In: Expert Review of Respiratory Medicine. 2019 ; Vol. 13, No. 10. pp. 969-979.
@article{5b24d7907716401b94659b47e487ca52,
title = "Contemporary management of bronchiectasis in children",
abstract = "Introduction: Bronchiectasis is increasingly recognized as a major cause of morbidity and mortality worldwide. It affects children of all ethnicities and socioeconomic backgrounds and represents a far greater burden than cystic fibrosis (CF). Bronchiectasis often begins in childhood and the radiological changes can be reversed, when mild, with optimal management. As there are limited pediatric studies in this field, current treatment approaches in children are based largely upon adult and/or CF studies. The recent establishment of bronchiectasis registries will improve understanding of pediatric bronchiectasis and increase capacity for large-scale research studies in the future. Areas covered: This review summarizes the current management of bronchiectasis in children and highlights important knowledge gaps and areas for future research. Current treatment approaches are based largely on consensus guidelines from international experts in the field. Studies were identified through searching Medline via the Ovid interface and Pubmed using the search terms ‘bronchiectasis’ and ‘children’ or ‘pediatric’ and ‘management’ or ‘treatments’. Expert opinion: Bronchiectasis is heterogeneous in nature and a one-size-fits-all approach has limitations. Future research should focus on advancing our understanding of the aetiopathogenesis of bronchiectasis. This approach will facilitate development of targetted therapeutic interventions to slow, halt or even reverse bronchiectasis in childhood.",
keywords = "airway clearance, chronic suppurative lung disease, Cough, haemophilus influenzae, macrolides, protracted bacterial bronchitis, pseudomonas",
author = "Johnny Wu and Chang, {Anne B.} and Wurzel, {Danielle F.}",
year = "2019",
month = "8",
day = "27",
doi = "10.1080/17476348.2019.1655400",
language = "English",
volume = "13",
pages = "969--979",
journal = "Expert Review of Respiratory Medicine",
issn = "1747-6348",
publisher = "Expert Reviews",
number = "10",

}

Contemporary management of bronchiectasis in children. / Wu, Johnny; Chang, Anne B.; Wurzel, Danielle F.

In: Expert Review of Respiratory Medicine, Vol. 13, No. 10, 27.08.2019, p. 969-979.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - Contemporary management of bronchiectasis in children

AU - Wu, Johnny

AU - Chang, Anne B.

AU - Wurzel, Danielle F.

PY - 2019/8/27

Y1 - 2019/8/27

N2 - Introduction: Bronchiectasis is increasingly recognized as a major cause of morbidity and mortality worldwide. It affects children of all ethnicities and socioeconomic backgrounds and represents a far greater burden than cystic fibrosis (CF). Bronchiectasis often begins in childhood and the radiological changes can be reversed, when mild, with optimal management. As there are limited pediatric studies in this field, current treatment approaches in children are based largely upon adult and/or CF studies. The recent establishment of bronchiectasis registries will improve understanding of pediatric bronchiectasis and increase capacity for large-scale research studies in the future. Areas covered: This review summarizes the current management of bronchiectasis in children and highlights important knowledge gaps and areas for future research. Current treatment approaches are based largely on consensus guidelines from international experts in the field. Studies were identified through searching Medline via the Ovid interface and Pubmed using the search terms ‘bronchiectasis’ and ‘children’ or ‘pediatric’ and ‘management’ or ‘treatments’. Expert opinion: Bronchiectasis is heterogeneous in nature and a one-size-fits-all approach has limitations. Future research should focus on advancing our understanding of the aetiopathogenesis of bronchiectasis. This approach will facilitate development of targetted therapeutic interventions to slow, halt or even reverse bronchiectasis in childhood.

AB - Introduction: Bronchiectasis is increasingly recognized as a major cause of morbidity and mortality worldwide. It affects children of all ethnicities and socioeconomic backgrounds and represents a far greater burden than cystic fibrosis (CF). Bronchiectasis often begins in childhood and the radiological changes can be reversed, when mild, with optimal management. As there are limited pediatric studies in this field, current treatment approaches in children are based largely upon adult and/or CF studies. The recent establishment of bronchiectasis registries will improve understanding of pediatric bronchiectasis and increase capacity for large-scale research studies in the future. Areas covered: This review summarizes the current management of bronchiectasis in children and highlights important knowledge gaps and areas for future research. Current treatment approaches are based largely on consensus guidelines from international experts in the field. Studies were identified through searching Medline via the Ovid interface and Pubmed using the search terms ‘bronchiectasis’ and ‘children’ or ‘pediatric’ and ‘management’ or ‘treatments’. Expert opinion: Bronchiectasis is heterogeneous in nature and a one-size-fits-all approach has limitations. Future research should focus on advancing our understanding of the aetiopathogenesis of bronchiectasis. This approach will facilitate development of targetted therapeutic interventions to slow, halt or even reverse bronchiectasis in childhood.

KW - airway clearance

KW - chronic suppurative lung disease

KW - Cough

KW - haemophilus influenzae

KW - macrolides

KW - protracted bacterial bronchitis

KW - pseudomonas

UR - http://www.scopus.com/inward/record.url?scp=85071317808&partnerID=8YFLogxK

U2 - 10.1080/17476348.2019.1655400

DO - 10.1080/17476348.2019.1655400

M3 - Review article

VL - 13

SP - 969

EP - 979

JO - Expert Review of Respiratory Medicine

JF - Expert Review of Respiratory Medicine

SN - 1747-6348

IS - 10

ER -