Crusted scabies is associated with increased IL-17 secretion by skin T cells

X. Liu, S. F. Walton, H. C. Murray, M. King, A. Kelly, D. C. Holt, B. J. Currie, J. S. Mccarthy, K. E. Mounsey

    Research output: Contribution to journalArticle

    Abstract

    Scabies is an ectoparasitic infestation by the mite Sarcoptes scabiei. Although commonly self-limiting, a fraction of patients develop severely debilitating crusted scabies. The immune mechanisms underlying the development of crusted scabies are unclear, and undertaking longitudinal infection studies in humans is difficult. We utilized a porcine model to compare cellular immune responses in peripheral blood and skin of pigs with different clinical manifestations of scabies (n = 12), and in uninfected controls (n = 6). Although clinical symptoms were not evident until at least 4 weeks post-infestation, the numbers of peripheral IFNγ-secreting CD4+ T cells and γδ T cells increased in infected pigs from week 1 post-infestation. γδ T cells remained increased in the blood at week 15 post-infestation. At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8+ T cell, γδ T cell and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localized skin IL-17-secreting T cells may play a critical role in the pathogenesis of crusted scabies development. Given the potential of anti-IL-17 immunotherapy demonstrated for other inflammatory skin diseases, this study may provide a novel therapeutic avenue for patients with recurrent crusted scabies.

    Original languageEnglish
    Pages (from-to)594-604
    Number of pages11
    JournalParasite Immunology
    Volume36
    Issue number11
    DOIs
    Publication statusPublished - 1 Nov 2014

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    Liu, X., Walton, S. F., Murray, H. C., King, M., Kelly, A., Holt, D. C., Currie, B. J., Mccarthy, J. S., & Mounsey, K. E. (2014). Crusted scabies is associated with increased IL-17 secretion by skin T cells. Parasite Immunology, 36(11), 594-604. https://doi.org/10.1111/pim.12129