Methods: We analyzed theassociation between DPI and clinical outcomes using multivariablelogistic regression, Cox proportional hazards modelsand time-adjusted analysis.
Results: During ICU stay,mean DPI was 37.6 g/day among survivors and 37.7 g/dayamong nonsurvivors (p = 0.96; DPI of 0.5 g/kg/day). Only 159(10.9%) of the patients received a mean DPI of >1 g/kg. Patientswith a DPI above the median had a 43.1% mortalitycompared with 46.1% for a DPI below the median (p = 0.25).On multivariate analysis, a lower DPI was not associated withincreased odds ratios for 90-day mortality or any secondaryoutcomes. Cox proportional hazards models and time-adjustedanalysis confirmed these findings.
Conclusions: In the RENAL study, mean DPI was low. Within the confines of suchlow DPI, greater amounts of DPI were not independently associatedwith improved clinical outcomes.