Daily Protein Intake and Patient Outcomes in Severe Acute Kidney Injury: Findings of the Randomized Evaluation of Normal versus Augmented Level of Replacement Therapy (RENAL) Trial

Rinaldo Bellomo; Alan Cass; Louise Cole; Simon Finfer; Martin Gallagher; Joanne Lee; Serigne Lo; Colin McArthur; Shay McGuinness; Robyn Norton; John Myburgh; Carlos Sheinkestel; null The RENAL Study Investigators

doi:10.1159/000363175

Daily Protein Intake and Patient Outcomes in Severe Acute Kidney Injury: Findings of the Randomized Evaluation of Normal versus Augmented Level of Replacement Therapy (RENAL) Trial

Rinaldo Bellomo, Alan Cass, Louise Cole, Simon Finfer, Martin Gallagher, Joanne Lee, Serigne Lo, Colin McArthur, Shay McGuinness, Robyn Norton, John Myburgh, Carlos Sheinkestel, The RENAL Study Investigators

Research output: Contribution to journal › Article › peer-review

Abstract

Background and Aims: We aimed to examine the associationbetween daily protein intake (DPI) and outcomes in patientsfrom the Randomized Evaluation of Normal versusAugmented Level (RENAL) trial.

Methods: We analyzed theassociation between DPI and clinical outcomes using multivariablelogistic regression, Cox proportional hazards modelsand time-adjusted analysis.

Results: During ICU stay,mean DPI was 37.6 g/day among survivors and 37.7 g/dayamong nonsurvivors (p = 0.96; DPI of 0.5 g/kg/day). Only 159(10.9%) of the patients received a mean DPI of >1 g/kg. Patientswith a DPI above the median had a 43.1% mortalitycompared with 46.1% for a DPI below the median (p = 0.25).On multivariate analysis, a lower DPI was not associated withincreased odds ratios for 90-day mortality or any secondaryoutcomes. Cox proportional hazards models and time-adjustedanalysis confirmed these findings.

Conclusions: In the RENAL study, mean DPI was low. Within the confines of suchlow DPI, greater amounts of DPI were not independently associatedwith improved clinical outcomes.

Original language	English
Pages (from-to)	325-334
Number of pages	10
Journal	Blood Purification
Volume	37
Issue number	4
DOIs	https://doi.org/10.1159/000363175
Publication status	Published - 2014

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Bellomo, R., Cass, A., Cole, L., Finfer, S., Gallagher, M., Lee, J., Lo, S., McArthur, C., McGuinness, S., Norton, R., Myburgh, J., Sheinkestel, C., & The RENAL Study Investigators (2014). Daily Protein Intake and Patient Outcomes in Severe Acute Kidney Injury: Findings of the Randomized Evaluation of Normal versus Augmented Level of Replacement Therapy (RENAL) Trial. Blood Purification, 37(4), 325-334. https://doi.org/10.1159/000363175

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title = "Daily Protein Intake and Patient Outcomes in Severe Acute Kidney Injury: Findings of the Randomized Evaluation of Normal versus Augmented Level of Replacement Therapy (RENAL) Trial",

abstract = "Background and Aims: We aimed to examine the associationbetween daily protein intake (DPI) and outcomes in patientsfrom the Randomized Evaluation of Normal versusAugmented Level (RENAL) trial. Methods: We analyzed theassociation between DPI and clinical outcomes using multivariablelogistic regression, Cox proportional hazards modelsand time-adjusted analysis. Results: During ICU stay,mean DPI was 37.6 g/day among survivors and 37.7 g/dayamong nonsurvivors (p = 0.96; DPI of 0.5 g/kg/day). Only 159(10.9%) of the patients received a mean DPI of >1 g/kg. Patientswith a DPI above the median had a 43.1% mortalitycompared with 46.1% for a DPI below the median (p = 0.25).On multivariate analysis, a lower DPI was not associated withincreased odds ratios for 90-day mortality or any secondaryoutcomes. Cox proportional hazards models and time-adjustedanalysis confirmed these findings. Conclusions: In the RENAL study, mean DPI was low. Within the confines of suchlow DPI, greater amounts of DPI were not independently associatedwith improved clinical outcomes.",

author = "Rinaldo Bellomo and Alan Cass and Louise Cole and Simon Finfer and Martin Gallagher and Joanne Lee and Serigne Lo and Colin McArthur and Shay McGuinness and Robyn Norton and John Myburgh and Carlos Sheinkestel and {The RENAL Study Investigators}",

year = "2014",

doi = "10.1159/000363175",

language = "English",

volume = "37",

pages = "325--334",

journal = "Blood Purification",

issn = "0253-5068",

publisher = "S Karger AG",

number = "4",

}

Bellomo, R, Cass, A, Cole, L, Finfer, S, Gallagher, M, Lee, J, Lo, S, McArthur, C, McGuinness, S, Norton, R, Myburgh, J, Sheinkestel, C & The RENAL Study Investigators 2014, 'Daily Protein Intake and Patient Outcomes in Severe Acute Kidney Injury: Findings of the Randomized Evaluation of Normal versus Augmented Level of Replacement Therapy (RENAL) Trial', Blood Purification, vol. 37, no. 4, pp. 325-334. https://doi.org/10.1159/000363175

TY - JOUR

T1 - Daily Protein Intake and Patient Outcomes in Severe Acute Kidney Injury

T2 - Findings of the Randomized Evaluation of Normal versus Augmented Level of Replacement Therapy (RENAL) Trial

AU - Bellomo, Rinaldo

AU - Cass, Alan

AU - Cole, Louise

AU - Finfer, Simon

AU - Gallagher, Martin

AU - Lee, Joanne

AU - Lo, Serigne

AU - McArthur, Colin

AU - McGuinness, Shay

AU - Norton, Robyn

AU - Myburgh, John

AU - Sheinkestel, Carlos

AU - The RENAL Study Investigators, null

PY - 2014

Y1 - 2014

N2 - Background and Aims: We aimed to examine the associationbetween daily protein intake (DPI) and outcomes in patientsfrom the Randomized Evaluation of Normal versusAugmented Level (RENAL) trial. Methods: We analyzed theassociation between DPI and clinical outcomes using multivariablelogistic regression, Cox proportional hazards modelsand time-adjusted analysis. Results: During ICU stay,mean DPI was 37.6 g/day among survivors and 37.7 g/dayamong nonsurvivors (p = 0.96; DPI of 0.5 g/kg/day). Only 159(10.9%) of the patients received a mean DPI of >1 g/kg. Patientswith a DPI above the median had a 43.1% mortalitycompared with 46.1% for a DPI below the median (p = 0.25).On multivariate analysis, a lower DPI was not associated withincreased odds ratios for 90-day mortality or any secondaryoutcomes. Cox proportional hazards models and time-adjustedanalysis confirmed these findings. Conclusions: In the RENAL study, mean DPI was low. Within the confines of suchlow DPI, greater amounts of DPI were not independently associatedwith improved clinical outcomes.

AB - Background and Aims: We aimed to examine the associationbetween daily protein intake (DPI) and outcomes in patientsfrom the Randomized Evaluation of Normal versusAugmented Level (RENAL) trial. Methods: We analyzed theassociation between DPI and clinical outcomes using multivariablelogistic regression, Cox proportional hazards modelsand time-adjusted analysis. Results: During ICU stay,mean DPI was 37.6 g/day among survivors and 37.7 g/dayamong nonsurvivors (p = 0.96; DPI of 0.5 g/kg/day). Only 159(10.9%) of the patients received a mean DPI of >1 g/kg. Patientswith a DPI above the median had a 43.1% mortalitycompared with 46.1% for a DPI below the median (p = 0.25).On multivariate analysis, a lower DPI was not associated withincreased odds ratios for 90-day mortality or any secondaryoutcomes. Cox proportional hazards models and time-adjustedanalysis confirmed these findings. Conclusions: In the RENAL study, mean DPI was low. Within the confines of suchlow DPI, greater amounts of DPI were not independently associatedwith improved clinical outcomes.

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U2 - 10.1159/000363175

DO - 10.1159/000363175

M3 - Article

VL - 37

SP - 325

EP - 334

JO - Blood Purification

JF - Blood Purification

SN - 0253-5068

IS - 4

ER -

Daily Protein Intake and Patient Outcomes in Severe Acute Kidney Injury: Findings of the Randomized Evaluation of Normal versus Augmented Level of Replacement Therapy (RENAL) Trial

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