Daily Protein Intake and Patient Outcomes in Severe Acute Kidney Injury: Findings of the Randomized Evaluation of Normal versus Augmented Level of Replacement Therapy (RENAL) Trial

Rinaldo Bellomo, Alan Cass, Louise Cole, Simon Finfer, Martin Gallagher, Joanne Lee, Serigne Lo, Colin McArthur, Shay McGuinness, Robyn Norton, John Myburgh, Carlos Sheinkestel, The RENAL Study Investigators

    Research output: Contribution to journalArticle


    Background and Aims: We aimed to examine the associationbetween daily protein intake (DPI) and outcomes in patientsfrom the Randomized Evaluation of Normal versusAugmented Level (RENAL) trial.

    We analyzed theassociation between DPI and clinical outcomes using multivariablelogistic regression, Cox proportional hazards modelsand time-adjusted analysis.

    During ICU stay,mean DPI was 37.6 g/day among survivors and 37.7 g/dayamong nonsurvivors (p = 0.96; DPI of 0.5 g/kg/day). Only 159(10.9%) of the patients received a mean DPI of >1 g/kg. Patientswith a DPI above the median had a 43.1% mortalitycompared with 46.1% for a DPI below the median (p = 0.25).On multivariate analysis, a lower DPI was not associated withincreased odds ratios for 90-day mortality or any secondaryoutcomes. Cox proportional hazards models and time-adjustedanalysis confirmed these findings.

    In the RENAL study, mean DPI was low. Within the confines of suchlow DPI, greater amounts of DPI were not independently associatedwith improved clinical outcomes.
    Original languageEnglish
    Pages (from-to)325-334
    Number of pages10
    JournalBlood Purification
    Issue number4
    Publication statusPublished - 2014


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