Decreased microvascular function in Tanzanian children with severe and uncomplicated falciparum malaria

Tsin W. Yeo; Salvatore M. Florence; Ayam R. Kalingonji; Youwei Chen; Donald L. Granger; Nicholas M. Anstey; Esther D. Mwaikambo; J. Brice Weinberg

doi:10.1093/ofid/ofx079

Decreased microvascular function in Tanzanian children with severe and uncomplicated falciparum malaria

Tsin W. Yeo, Salvatore M. Florence, Ayam R. Kalingonji, Youwei Chen, Donald L. Granger, Nicholas M. Anstey, Esther D. Mwaikambo, J. Brice Weinberg

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Abstract

Microvascular function and oxygen consumption affect oxygen homeostasis but have not been assessed in African children with malaria. Microvascular function in Tanzanian children with severe malaria (SM) or uncomplicated malaria were 39% and 72%, respectively, of controls (P < .001). Uncomplicated malaria (P = .04), not SM (P = .06), children had increased oxygen consumption compared with controls.

Original language	English
Article number	ofx079
Pages (from-to)	1-4
Number of pages	4
Journal	Open Forum Infectious Diseases
Volume	4
Issue number	2
DOIs	https://doi.org/10.1093/ofid/ofx079
Publication status	Published - 22 Apr 2017

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title = "Decreased microvascular function in Tanzanian children with severe and uncomplicated falciparum malaria",

abstract = "Microvascular function and oxygen consumption affect oxygen homeostasis but have not been assessed in African children with malaria. Microvascular function in Tanzanian children with severe malaria (SM) or uncomplicated malaria were 39% and 72%, respectively, of controls (P < .001). Uncomplicated malaria (P = .04), not SM (P = .06), children had increased oxygen consumption compared with controls.",

keywords = "Microvascular function, Oxygen consumption, Plasmodium falciparum, Severe malaria",

author = "Yeo, {Tsin W.} and Florence, {Salvatore M.} and Kalingonji, {Ayam R.} and Youwei Chen and Granger, {Donald L.} and Anstey, {Nicholas M.} and Mwaikambo, {Esther D.} and Weinberg, {J. Brice}",

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AU - Yeo, Tsin W.

AU - Florence, Salvatore M.

AU - Kalingonji, Ayam R.

AU - Chen, Youwei

AU - Granger, Donald L.

AU - Anstey, Nicholas M.

AU - Mwaikambo, Esther D.

AU - Weinberg, J. Brice

PY - 2017/4/22

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N2 - Microvascular function and oxygen consumption affect oxygen homeostasis but have not been assessed in African children with malaria. Microvascular function in Tanzanian children with severe malaria (SM) or uncomplicated malaria were 39% and 72%, respectively, of controls (P < .001). Uncomplicated malaria (P = .04), not SM (P = .06), children had increased oxygen consumption compared with controls.

AB - Microvascular function and oxygen consumption affect oxygen homeostasis but have not been assessed in African children with malaria. Microvascular function in Tanzanian children with severe malaria (SM) or uncomplicated malaria were 39% and 72%, respectively, of controls (P < .001). Uncomplicated malaria (P = .04), not SM (P = .06), children had increased oxygen consumption compared with controls.

KW - Microvascular function

KW - Oxygen consumption

KW - Plasmodium falciparum

KW - Severe malaria

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Decreased microvascular function in Tanzanian children with severe and uncomplicated falciparum malaria

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