Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010

George Mtove, Ben Amos, Behzad Nadjm, Ilse C E Hendriksen, Arjen M. Dondorp, Abraham Mwambuli, Deok Ryun Kim, R. Leon Ochiai, John D. Clemens, Lorenz Von Seidlein, Hugh Reyburn, Jacqueline Deen

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    Abstract

    Background: The annual incidence and temporal trend of severe malaria and community-acquired bacteraemia during a four-year period in Muheza, Tanzania was assessed. 

    Methods: Data on severely ill febrile children aged 2 months to 14 years from three prospective studies conducted at Muheza District Hospital from 2006 to 2010 was pooled and analysed. On admission, each enrolled child had a thin and thick blood film and at least one rapid diagnostic test for falciparum malaria, as well as a blood culture. The annual incidence of bacteraemia and severe malaria among children coming from Muheza was calculated and their temporal trend was assessed. 

    Results: Overall, 1, 898 severe falciparum malaria and 684 bacteraemia cases were included. Of these, 1, 356 (71%) and 482 (71%), respectively, were from the referral population of Muheza. The incidence of falciparum malaria and all-cause bacteraemia in Muheza decreased five-fold and three-fold, respectively, from the first to the fourth year of surveillance (p < 0.0001). During this period, the median ages of children from Muheza admitted with severe malaria increased from 1.7 to 2.5 years (p < 0.0001). The reduction in all-cause bacteraemia was mainly driven by the 11-fold decline in the incidence of non-typhoidal salmonellosis. The annual incidences of Haemophilus influenzae and pneumococcal invasive bacterial infections decreased as well but were much fewer in number. 

    Conclusions: These results add to the growing evidence of the decline in malaria associated with a decrease in non-typhoidal salmonellosis and possibly other bacteraemias. Malarial prevention and control strategies may provide a greater benefit than the mere reduction of malaria alone.

    Original languageEnglish
    Article number320
    Pages (from-to)1-11
    Number of pages11
    JournalMalaria Journal
    Volume10
    DOIs
    Publication statusPublished - 2011

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    Mtove, G., Amos, B., Nadjm, B., Hendriksen, I. C. E., Dondorp, A. M., Mwambuli, A., Kim, D. R., Ochiai, R. L., Clemens, J. D., Von Seidlein, L., Reyburn, H., & Deen, J. (2011). Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010. Malaria Journal, 10, 1-11. [320]. https://doi.org/10.1186/1475-2875-10-320