Delayed Diagnosis of Whipple’s Disease Complicated by Jarisch–Herxheimer Reaction to Ceftriaxone Treatment: A Case Report and Literature Review

Marcus C.C. Clarke; Ric N. Price

doi:10.3390/tropicalmed7030040

Delayed Diagnosis of Whipple’s Disease Complicated by Jarisch–Herxheimer Reaction to Ceftriaxone Treatment: A Case Report and Literature Review

Marcus C.C. Clarke, Ric N. Price

Global and Tropical Health

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Abstract

Whipple’s disease is a rare chronic infection caused by the actinomycete Tropheryma whipplei. Patients commonly present with gastrointestinal symptoms. We present a case of classic Whipple’s disease complicated by a probable Jarisch–Herxheimer reaction following the initiation of ceftriaxone treatment.

Original language	English
Article number	40
Pages (from-to)	1-4
Number of pages	4
Journal	Tropical Medicine and Infectious Disease
Volume	7
Issue number	3
DOIs	https://doi.org/10.3390/tropicalmed7030040
Publication status	Published - Mar 2022

Bibliographical note

Funding Information:
RNP is a Wellcome Trust Senior Fellow in Clinical Science (200909).

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

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10.3390/tropicalmed7030040

55927404-oaFinal published version, 214 KBLicence: CC BY

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title = "Delayed Diagnosis of Whipple{\textquoteright}s Disease Complicated by Jarisch–Herxheimer Reaction to Ceftriaxone Treatment: A Case Report and Literature Review",

abstract = "Whipple{\textquoteright}s disease is a rare chronic infection caused by the actinomycete Tropheryma whipplei. Patients commonly present with gastrointestinal symptoms. We present a case of classic Whipple{\textquoteright}s disease complicated by a probable Jarisch–Herxheimer reaction following the initiation of ceftriaxone treatment.",

keywords = "Antimicrobial treatment, Jarisch–Herxheimer reaction, Whipple{\textquoteright}s disease",

author = "Clarke, {Marcus C.C.} and Price, {Ric N.}",

note = "Funding Information: RNP is a Wellcome Trust Senior Fellow in Clinical Science (200909). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

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language = "English",

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AU - Clarke, Marcus C.C.

AU - Price, Ric N.

PY - 2022/3

Y1 - 2022/3

N2 - Whipple’s disease is a rare chronic infection caused by the actinomycete Tropheryma whipplei. Patients commonly present with gastrointestinal symptoms. We present a case of classic Whipple’s disease complicated by a probable Jarisch–Herxheimer reaction following the initiation of ceftriaxone treatment.

AB - Whipple’s disease is a rare chronic infection caused by the actinomycete Tropheryma whipplei. Patients commonly present with gastrointestinal symptoms. We present a case of classic Whipple’s disease complicated by a probable Jarisch–Herxheimer reaction following the initiation of ceftriaxone treatment.

KW - Antimicrobial treatment

KW - Jarisch–Herxheimer reaction

KW - Whipple’s disease

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DO - 10.3390/tropicalmed7030040

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Delayed Diagnosis of Whipple’s Disease Complicated by Jarisch–Herxheimer Reaction to Ceftriaxone Treatment: A Case Report and Literature Review

Abstract

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