Abstract
Diabetes in pregnancy is not only associated with increased risk of pregnancy complications and subsequent maternal metabolic disease, but also increases the risk of long-term metabolic disease in the offspring. At the interface between genetic and environmental factors, epigenetic variation established in utero represents a plausible link between the in utero environment and later disease susceptibility. The identification of an epigenetic fingerprint of diabetes in pregnancy linked to the metabolic health of the offspring might provide novel biomarkers for the identification of offspring most at risk, before the onset of metabolic dysfunction, for targeted monitoring and intervention. In this Personal View, we (1) highlight the scale of the problem of diabetes in pregnancy, (2) summarise evidence for the variation in offspring epigenetic profiles following exposure to diabetes in utero, and (3) outline potential future approaches to further understand the mechanisms by which exposure to maternal metabolic dysfunction in pregnancy is transmitted through generations.
| Original language | English |
|---|---|
| Pages (from-to) | 796-806 |
| Number of pages | 11 |
| Journal | The Lancet Diabetes and Endocrinology |
| Volume | 7 |
| Issue number | 10 |
| Early online date | 22 May 2019 |
| DOIs | |
| Publication status | Published - 1 Oct 2019 |
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Diabetes in pregnancy and epigenetic mechanisms : how the first 9 months from conception might affect the child's epigenome and later risk of disease. / Hjort, Line; Novakovic , Boris; Grunnet , Louise G ; Maple-Brown, Louise; Damm, Peter; Desoye, Gernot ; Saffery, Richard.
In: The Lancet Diabetes and Endocrinology, Vol. 7, No. 10, 01.10.2019, p. 796-806.Research output: Contribution to journal › Review article › Research › peer-review
TY - JOUR
T1 - Diabetes in pregnancy and epigenetic mechanisms
T2 - how the first 9 months from conception might affect the child's epigenome and later risk of disease
AU - Hjort, Line
AU - Novakovic , Boris
AU - Grunnet , Louise G
AU - Maple-Brown, Louise
AU - Damm, Peter
AU - Desoye, Gernot
AU - Saffery, Richard
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Diabetes in pregnancy is not only associated with increased risk of pregnancy complications and subsequent maternal metabolic disease, but also increases the risk of long-term metabolic disease in the offspring. At the interface between genetic and environmental factors, epigenetic variation established in utero represents a plausible link between the in utero environment and later disease susceptibility. The identification of an epigenetic fingerprint of diabetes in pregnancy linked to the metabolic health of the offspring might provide novel biomarkers for the identification of offspring most at risk, before the onset of metabolic dysfunction, for targeted monitoring and intervention. In this Personal View, we (1) highlight the scale of the problem of diabetes in pregnancy, (2) summarise evidence for the variation in offspring epigenetic profiles following exposure to diabetes in utero, and (3) outline potential future approaches to further understand the mechanisms by which exposure to maternal metabolic dysfunction in pregnancy is transmitted through generations.
AB - Diabetes in pregnancy is not only associated with increased risk of pregnancy complications and subsequent maternal metabolic disease, but also increases the risk of long-term metabolic disease in the offspring. At the interface between genetic and environmental factors, epigenetic variation established in utero represents a plausible link between the in utero environment and later disease susceptibility. The identification of an epigenetic fingerprint of diabetes in pregnancy linked to the metabolic health of the offspring might provide novel biomarkers for the identification of offspring most at risk, before the onset of metabolic dysfunction, for targeted monitoring and intervention. In this Personal View, we (1) highlight the scale of the problem of diabetes in pregnancy, (2) summarise evidence for the variation in offspring epigenetic profiles following exposure to diabetes in utero, and (3) outline potential future approaches to further understand the mechanisms by which exposure to maternal metabolic dysfunction in pregnancy is transmitted through generations.
UR - http://www.scopus.com/inward/record.url?scp=85072195647&partnerID=8YFLogxK
U2 - 10.1016/S2213-8587(19)30078-6
DO - 10.1016/S2213-8587(19)30078-6
M3 - Review article
VL - 7
SP - 796
EP - 806
JO - The Lancet Diabetes and Endocrinology
JF - The Lancet Diabetes and Endocrinology
SN - 2213-8587
IS - 10
ER -