Diagnosis and treatment of invasive group A streptococcal infections

Andrew Steer, Nigel Curtis, Jonathan Carapetis

    Research output: Contribution to journalArticle

    Abstract

    Background: Invasive group A streptococcal infections are serious infections that carry a high mortality. Objective: The aim was to review current methods of diagnosis and treatment of invasive group A streptococcal infections as well as to provide background on the pathogenesis and epidemiology of these infections. Methods: The most recent literature regarding pathogenesis, epidemiology, diagnosis and treatment of invasive group A streptococcal infections is reviewed. Results/conclusion: The incidence of invasive group A streptococcal infections in industrialised countries is in the order of 3 per 100,000, whereas in developing countries available evidence suggests that the incidence is several-fold higher. Management of invasive group A streptococcal infections includes supportive care, surgical debridement of necrotic tissue, correct use of antibiotics, intravenous immunoglobulin and contact prophylaxis. Recent studies suggest that the early use of intravenous immunoglobulin may reduce the need for radical debridement of tissue in cases of necrotising fasciitis. � 2008 Informa UK Ltd.
    Original languageEnglish
    Pages (from-to)289-301
    Number of pages13
    JournalExpert Opinion on Medical Diagnostics
    Volume2
    Issue number3
    Publication statusPublished - 2008

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