Differentials in survival for childhood cancer in Australia by remoteness of residence and area disadvantage

Danny Youlden, Peter Baade, Patricia Valery, Leisa Ward, Adèle Green, Joanne Aitken

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: It is not known whether improvements in cancer survival over recent decades have benefited children from different geographic locations equally. This is the first study to produce national survival estimates for childhood cancer in Australia by remoteness of residence and area-based socioeconomic status.

Methods: The study utilized population-based data from the Australian Paediatric Cancer Registry for children diagnosed with cancer from 1996 onward who were at risk of mortality between January 2001 and December 2006 (n = 6,289). Remoteness was specified according to the Australian Standard Geographical Classification Remoteness Areas, whereas an index of area disadvantage was obtained from census information. Five-year relative survival estimates were produced by the period method for all cancers and the most common diagnostic groups, with corresponding age–sex adjusted mortality hazard ratios calculated using Poisson regression.

Results: Overall, children with cancer from remote/very remote areas had a significantly lower survival rate than their counterparts in major cities (HR = 1.55, 95% CI = 1.08–2.23). Survival was also lower for children with leukemia living in inner regional (HR = 1.52, 95% CI = 1.11–2.08) or outer regional areas (HR = 1.53, 95% CI = 1.03–2.28). There was weak evidence (Pgrad = 0.051) of a trend toward poorer survival by greater area disadvantage for all childhood cancers.

Conclusions: Some variation in prognosis by place of residence was present for children with cancer in Australia, particularly among leukemia patients.

Impact: Treatment, clinical or area-related factors that contribute to these survival differentials need to be identified.
Original languageEnglish
Pages (from-to)1649-1656
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume20
Issue number8
DOIs
Publication statusPublished - 2011
Externally publishedYes

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Survival
Neoplasms
Leukemia
Geographic Locations
Mortality
Censuses
Social Class
Registries
Survival Rate
Pediatrics
Population
Therapeutics

Cite this

Youlden, Danny ; Baade, Peter ; Valery, Patricia ; Ward, Leisa ; Green, Adèle ; Aitken, Joanne. / Differentials in survival for childhood cancer in Australia by remoteness of residence and area disadvantage. In: Cancer Epidemiology Biomarkers and Prevention. 2011 ; Vol. 20, No. 8. pp. 1649-1656.
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abstract = "Background: It is not known whether improvements in cancer survival over recent decades have benefited children from different geographic locations equally. This is the first study to produce national survival estimates for childhood cancer in Australia by remoteness of residence and area-based socioeconomic status.Methods: The study utilized population-based data from the Australian Paediatric Cancer Registry for children diagnosed with cancer from 1996 onward who were at risk of mortality between January 2001 and December 2006 (n = 6,289). Remoteness was specified according to the Australian Standard Geographical Classification Remoteness Areas, whereas an index of area disadvantage was obtained from census information. Five-year relative survival estimates were produced by the period method for all cancers and the most common diagnostic groups, with corresponding age–sex adjusted mortality hazard ratios calculated using Poisson regression.Results: Overall, children with cancer from remote/very remote areas had a significantly lower survival rate than their counterparts in major cities (HR = 1.55, 95{\%} CI = 1.08–2.23). Survival was also lower for children with leukemia living in inner regional (HR = 1.52, 95{\%} CI = 1.11–2.08) or outer regional areas (HR = 1.53, 95{\%} CI = 1.03–2.28). There was weak evidence (Pgrad = 0.051) of a trend toward poorer survival by greater area disadvantage for all childhood cancers.Conclusions: Some variation in prognosis by place of residence was present for children with cancer in Australia, particularly among leukemia patients.Impact: Treatment, clinical or area-related factors that contribute to these survival differentials need to be identified.",
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Differentials in survival for childhood cancer in Australia by remoteness of residence and area disadvantage. / Youlden, Danny; Baade, Peter; Valery, Patricia ; Ward, Leisa; Green, Adèle; Aitken, Joanne.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 20, No. 8, 2011, p. 1649-1656.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Differentials in survival for childhood cancer in Australia by remoteness of residence and area disadvantage

AU - Youlden, Danny

AU - Baade, Peter

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AU - Aitken, Joanne

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N2 - Background: It is not known whether improvements in cancer survival over recent decades have benefited children from different geographic locations equally. This is the first study to produce national survival estimates for childhood cancer in Australia by remoteness of residence and area-based socioeconomic status.Methods: The study utilized population-based data from the Australian Paediatric Cancer Registry for children diagnosed with cancer from 1996 onward who were at risk of mortality between January 2001 and December 2006 (n = 6,289). Remoteness was specified according to the Australian Standard Geographical Classification Remoteness Areas, whereas an index of area disadvantage was obtained from census information. Five-year relative survival estimates were produced by the period method for all cancers and the most common diagnostic groups, with corresponding age–sex adjusted mortality hazard ratios calculated using Poisson regression.Results: Overall, children with cancer from remote/very remote areas had a significantly lower survival rate than their counterparts in major cities (HR = 1.55, 95% CI = 1.08–2.23). Survival was also lower for children with leukemia living in inner regional (HR = 1.52, 95% CI = 1.11–2.08) or outer regional areas (HR = 1.53, 95% CI = 1.03–2.28). There was weak evidence (Pgrad = 0.051) of a trend toward poorer survival by greater area disadvantage for all childhood cancers.Conclusions: Some variation in prognosis by place of residence was present for children with cancer in Australia, particularly among leukemia patients.Impact: Treatment, clinical or area-related factors that contribute to these survival differentials need to be identified.

AB - Background: It is not known whether improvements in cancer survival over recent decades have benefited children from different geographic locations equally. This is the first study to produce national survival estimates for childhood cancer in Australia by remoteness of residence and area-based socioeconomic status.Methods: The study utilized population-based data from the Australian Paediatric Cancer Registry for children diagnosed with cancer from 1996 onward who were at risk of mortality between January 2001 and December 2006 (n = 6,289). Remoteness was specified according to the Australian Standard Geographical Classification Remoteness Areas, whereas an index of area disadvantage was obtained from census information. Five-year relative survival estimates were produced by the period method for all cancers and the most common diagnostic groups, with corresponding age–sex adjusted mortality hazard ratios calculated using Poisson regression.Results: Overall, children with cancer from remote/very remote areas had a significantly lower survival rate than their counterparts in major cities (HR = 1.55, 95% CI = 1.08–2.23). Survival was also lower for children with leukemia living in inner regional (HR = 1.52, 95% CI = 1.11–2.08) or outer regional areas (HR = 1.53, 95% CI = 1.03–2.28). There was weak evidence (Pgrad = 0.051) of a trend toward poorer survival by greater area disadvantage for all childhood cancers.Conclusions: Some variation in prognosis by place of residence was present for children with cancer in Australia, particularly among leukemia patients.Impact: Treatment, clinical or area-related factors that contribute to these survival differentials need to be identified.

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