Disease Severity and Effective Parasite Multiplication Rate in falciparum Malaria

Hugh William Fluellen Kingston, Aniruddha Ghose, Katherine Plewes, Haruhiko Ishioka, Stije J Leopold, Richard J. Maude, Sanjib Paul, Benjamas Intharabut, Kamorat Silamut, Charles J. Woodrow, Nicholas P J Day, Kesinee Chotivanich, Nicholas Anstey, Amir Hossain, Nicholas J White, Arjen M. Dondorp

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    Patients presenting with severe falciparum malaria in a Bangladeshi tertiary hospital had higher total parasite burden, estimated by parasitemia and plasma PfHRP2, than uncomplicated malaria patients despite shorter fever duration. This suggests that higher parasite multiplication rates (PMR) contribute to causing the higher biomass found in severe disease. Compared with patients without a history of previous malaria, patients with previous malaria carried a lower parasite biomass with similar fever duration at presentation, suggesting that host immunity reduces the PMR.
    Original languageEnglish
    Pages (from-to)1-4
    Number of pages4
    JournalOpen Forum Infectious Diseases
    Issue number4
    Publication statusPublished - 2017


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