Disease Severity and Effective Parasite Multiplication Rate in falciparum Malaria

Hugh William Fluellen Kingston; Aniruddha Ghose; Katherine Plewes; Haruhiko Ishioka; Stije J Leopold; Richard J. Maude; Sanjib  Paul; Benjamas Intharabut; Kamorat  Silamut; Charles J. Woodrow; Nicholas P J Day; Kesinee Chotivanich; Nicholas Anstey; Amir Hossain; Nicholas J White; Arjen M. Dondorp

doi:10.1093/ofid/ofx169

Disease Severity and Effective Parasite Multiplication Rate in falciparum Malaria

Hugh William Fluellen Kingston, Aniruddha Ghose, Katherine Plewes, Haruhiko Ishioka, Stije J Leopold, Richard J. Maude, Sanjib Paul, Benjamas Intharabut, Kamorat Silamut, Charles J. Woodrow, Nicholas P J Day, Kesinee Chotivanich, Nicholas Anstey, Amir Hossain, Nicholas J White, Arjen M. Dondorp

Global and Tropical Health

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Abstract

Patients presenting with severe falciparum malaria in a Bangladeshi tertiary hospital had higher total parasite burden, estimated by parasitemia and plasma PfHRP2, than uncomplicated malaria patients despite shorter fever duration. This suggests that higher parasite multiplication rates (PMR) contribute to causing the higher biomass found in severe disease. Compared with patients without a history of previous malaria, patients with previous malaria carried a lower parasite biomass with similar fever duration at presentation, suggesting that host immunity reduces the PMR.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Open Forum Infectious Diseases
Volume	4
Issue number	4
DOIs	https://doi.org/10.1093/ofid/ofx169
Publication status	Published - 2017

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2017 Kingston et al PMR SM OFIDFinal published version, 262 KB

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Kingston, H. W. F., Ghose, A., Plewes, K., Ishioka, H., Leopold, S. J., Maude, R. J., Paul, S., Intharabut, B., Silamut, K., Woodrow, C. J., Day, N. P. J., Chotivanich, K., Anstey, N., Hossain, A., White, N. J., & Dondorp, A. M. (2017). Disease Severity and Effective Parasite Multiplication Rate in falciparum Malaria. Open Forum Infectious Diseases, 4(4), 1-4. https://doi.org/10.1093/ofid/ofx169

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title = "Disease Severity and Effective Parasite Multiplication Rate in falciparum Malaria",

abstract = "Patients presenting with severe falciparum malaria in a Bangladeshi tertiary hospital had higher total parasite burden, estimated by parasitemia and plasma PfHRP2, than uncomplicated malaria patients despite shorter fever duration. This suggests that higher parasite multiplication rates (PMR) contribute to causing the higher biomass found in severe disease. Compared with patients without a history of previous malaria, patients with previous malaria carried a lower parasite biomass with similar fever duration at presentation, suggesting that host immunity reduces the PMR.",

author = "Kingston, {Hugh William Fluellen} and Aniruddha Ghose and Katherine Plewes and Haruhiko Ishioka and Leopold, {Stije J} and Maude, {Richard J.} and Sanjib Paul and Benjamas Intharabut and Kamorat Silamut and Woodrow, {Charles J.} and Day, {Nicholas P J} and Kesinee Chotivanich and Nicholas Anstey and Amir Hossain and White, {Nicholas J} and Dondorp, {Arjen M.}",

year = "2017",

doi = "10.1093/ofid/ofx169",

language = "English",

volume = "4",

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Kingston, HWF, Ghose, A, Plewes, K, Ishioka, H, Leopold, SJ, Maude, RJ, Paul, S, Intharabut, B, Silamut, K, Woodrow, CJ, Day, NPJ, Chotivanich, K, Anstey, N, Hossain, A, White, NJ & Dondorp, AM 2017, 'Disease Severity and Effective Parasite Multiplication Rate in falciparum Malaria', Open Forum Infectious Diseases, vol. 4, no. 4, pp. 1-4. https://doi.org/10.1093/ofid/ofx169

TY - JOUR

T1 - Disease Severity and Effective Parasite Multiplication Rate in falciparum Malaria

AU - Kingston, Hugh William Fluellen

AU - Ghose, Aniruddha

AU - Plewes, Katherine

AU - Ishioka, Haruhiko

AU - Leopold, Stije J

AU - Maude, Richard J.

AU - Paul, Sanjib

AU - Intharabut, Benjamas

AU - Silamut, Kamorat

AU - Woodrow, Charles J.

AU - Day, Nicholas P J

AU - Chotivanich, Kesinee

AU - Anstey, Nicholas

AU - Hossain, Amir

AU - White, Nicholas J

AU - Dondorp, Arjen M.

PY - 2017

Y1 - 2017

N2 - Patients presenting with severe falciparum malaria in a Bangladeshi tertiary hospital had higher total parasite burden, estimated by parasitemia and plasma PfHRP2, than uncomplicated malaria patients despite shorter fever duration. This suggests that higher parasite multiplication rates (PMR) contribute to causing the higher biomass found in severe disease. Compared with patients without a history of previous malaria, patients with previous malaria carried a lower parasite biomass with similar fever duration at presentation, suggesting that host immunity reduces the PMR.

AB - Patients presenting with severe falciparum malaria in a Bangladeshi tertiary hospital had higher total parasite burden, estimated by parasitemia and plasma PfHRP2, than uncomplicated malaria patients despite shorter fever duration. This suggests that higher parasite multiplication rates (PMR) contribute to causing the higher biomass found in severe disease. Compared with patients without a history of previous malaria, patients with previous malaria carried a lower parasite biomass with similar fever duration at presentation, suggesting that host immunity reduces the PMR.

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U2 - 10.1093/ofid/ofx169

DO - 10.1093/ofid/ofx169

M3 - Article

C2 - 29302604

SN - 2328-8957

VL - 4

SP - 1

EP - 4

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 4

ER -

Disease Severity and Effective Parasite Multiplication Rate in falciparum Malaria

Abstract

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