Disseminated Saksenaea infection in an immunocompromised host associated with a good clinical outcome: A case report and review of the literature

N. Davidson; K. Campbell; F. Foroughi; V. Tayal; S. Lynar; L. C. Crawford; S. E. Kidd; R. Baird; J. Davies; E. M. Meumann

doi:10.1186/s12879-020-05459-9

Disseminated Saksenaea infection in an immunocompromised host associated with a good clinical outcome: A case report and review of the literature

N. Davidson, K. Campbell, F. Foroughi, V. Tayal, S. Lynar, L. C. Crawford, S. E. Kidd, R. Baird, J. Davies, E. M. Meumann

Research output: Contribution to journal › Article › peer-review

74 Downloads (Pure)

Abstract

Background: Saksenaea species (spp.) are uncommon causes of mucormycosis but are emerging pathogens mostly associated with trauma and soil contamination often in immunocompetent hosts. Due to lack of sporulation in the laboratory, diagnosis and susceptibility testing is difficult so optimal treatment regimens are unknown.

Case presentation: A 67 year-old man from the Northern Territory in Australia, with a history of eosinophilic granulomatosis with polyangiitis, developed disseminated Saksenaea infection after initially presenting with symptoms consistent with bacterial pyelonephritis. Despite a delay in diagnosis; with aggressive surgical management and dual therapy with amphotericin B and posaconazole, he survived.

Conclusions: We describe an unusual case of disseminated infection with a favourable outcome to date.

Original language	English
Article number	755
Pages (from-to)	1-5
Number of pages	5
Journal	BMC Infectious Diseases
Volume	20
Issue number	1
DOIs	https://doi.org/10.1186/s12879-020-05459-9
Publication status	Published - 1 Dec 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s12879-020-05459-9Licence: CC BY

35105951-oaFinal published version, 2.82 MBLicence: CC BY

Cite this

Davidson, N., Campbell, K., Foroughi, F., Tayal, V., Lynar, S., Crawford, L. C., Kidd, S. E., Baird, R., Davies, J., & Meumann, E. M. (2020). Disseminated Saksenaea infection in an immunocompromised host associated with a good clinical outcome: A case report and review of the literature. BMC Infectious Diseases, 20(1), 1-5. Article 755. https://doi.org/10.1186/s12879-020-05459-9

@article{6b39ffa86d5341f5a41990747c6651b8,

title = "Disseminated Saksenaea infection in an immunocompromised host associated with a good clinical outcome: A case report and review of the literature",

abstract = "Background: Saksenaea species (spp.) are uncommon causes of mucormycosis but are emerging pathogens mostly associated with trauma and soil contamination often in immunocompetent hosts. Due to lack of sporulation in the laboratory, diagnosis and susceptibility testing is difficult so optimal treatment regimens are unknown. Case presentation: A 67 year-old man from the Northern Territory in Australia, with a history of eosinophilic granulomatosis with polyangiitis, developed disseminated Saksenaea infection after initially presenting with symptoms consistent with bacterial pyelonephritis. Despite a delay in diagnosis; with aggressive surgical management and dual therapy with amphotericin B and posaconazole, he survived. Conclusions: We describe an unusual case of disseminated infection with a favourable outcome to date.",

keywords = "Amphotericin B, Disseminated fungal infection, Mucormycosis, Posaconazole",

author = "N. Davidson and K. Campbell and F. Foroughi and V. Tayal and S. Lynar and Crawford, {L. C.} and Kidd, {S. E.} and R. Baird and J. Davies and Meumann, {E. M.}",

year = "2020",

month = dec,

day = "1",

doi = "10.1186/s12879-020-05459-9",

language = "English",

volume = "20",

pages = "1--5",

journal = "BMC Infectious Diseases",

issn = "1471-2334",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - Disseminated Saksenaea infection in an immunocompromised host associated with a good clinical outcome

T2 - A case report and review of the literature

AU - Davidson, N.

AU - Campbell, K.

AU - Foroughi, F.

AU - Tayal, V.

AU - Lynar, S.

AU - Crawford, L. C.

AU - Kidd, S. E.

AU - Baird, R.

AU - Davies, J.

AU - Meumann, E. M.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Background: Saksenaea species (spp.) are uncommon causes of mucormycosis but are emerging pathogens mostly associated with trauma and soil contamination often in immunocompetent hosts. Due to lack of sporulation in the laboratory, diagnosis and susceptibility testing is difficult so optimal treatment regimens are unknown. Case presentation: A 67 year-old man from the Northern Territory in Australia, with a history of eosinophilic granulomatosis with polyangiitis, developed disseminated Saksenaea infection after initially presenting with symptoms consistent with bacterial pyelonephritis. Despite a delay in diagnosis; with aggressive surgical management and dual therapy with amphotericin B and posaconazole, he survived. Conclusions: We describe an unusual case of disseminated infection with a favourable outcome to date.

AB - Background: Saksenaea species (spp.) are uncommon causes of mucormycosis but are emerging pathogens mostly associated with trauma and soil contamination often in immunocompetent hosts. Due to lack of sporulation in the laboratory, diagnosis and susceptibility testing is difficult so optimal treatment regimens are unknown. Case presentation: A 67 year-old man from the Northern Territory in Australia, with a history of eosinophilic granulomatosis with polyangiitis, developed disseminated Saksenaea infection after initially presenting with symptoms consistent with bacterial pyelonephritis. Despite a delay in diagnosis; with aggressive surgical management and dual therapy with amphotericin B and posaconazole, he survived. Conclusions: We describe an unusual case of disseminated infection with a favourable outcome to date.

KW - Amphotericin B

KW - Disseminated fungal infection

KW - Mucormycosis

KW - Posaconazole

UR - http://www.scopus.com/inward/record.url?scp=85092645834&partnerID=8YFLogxK

U2 - 10.1186/s12879-020-05459-9

DO - 10.1186/s12879-020-05459-9

M3 - Article

C2 - 33054720

AN - SCOPUS:85092645834

SN - 1471-2334

VL - 20

SP - 1

EP - 5

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

IS - 1

M1 - 755

ER -

Disseminated Saksenaea infection in an immunocompromised host associated with a good clinical outcome: A case report and review of the literature

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this