Dissociable effects of tryptophan supplementation on negative feedback sensitivity and reversal learning

Martin Thirkettle, Laura Marie Barker, Thomas Gallagher, Nazgol Nayeb, Luca Aquili

Research output: Contribution to journalArticle

3 Downloads (Pure)

Abstract

Serotonin has been shown to modulate probabilistic reversal learning (PRL) and negative feedback sensitivity (NFS) in both animal and human studies. Whilst these two measures are tightly coupled, some studies have suggested that these may be mediated by independent mechanisms; the former, representing perseveration and cognitive flexibility, and the latter measuring the ability to maintain a response set (win-stay) at the expense of lose-shift behavior when occasional misleading feedback has been presented. Here, we tested this hypothesis in 44 healthy participants who were administered tryptophan (22 placebo, 22 tryptophan), a precursor to serotonin. We found a dissociable effect of tryptophan supplementation on PRL/NFS. Specifically, tryptophan administration increased NFS compared to the placebo group but had no effect on PRL. We discuss these findings in relation to dosages and with a particular focus on the acute tryptophan depletion (ATD) procedures.

Original languageEnglish
Article number127
JournalFrontiers in Behavioral Neuroscience
Volume13
DOIs
Publication statusPublished - 22 May 2019
Externally publishedYes

Fingerprint Dive into the research topics of 'Dissociable effects of tryptophan supplementation on negative feedback sensitivity and reversal learning'. Together they form a unique fingerprint.

Cite this