Do We Need A Wider Therapeutic Paradigm For Heart Failure With Comorbidities? A Remote Australian Perspective.

Pupalan Iyngkaran, Thomas M., Prashanthan Sanders, D.L Hare, Sandawana William Majoni, Stephen Brady, K Nadarajan , Marcus ILTON, A Brown

    Research output: Contribution to journalReview articleResearchpeer-review

    Abstract

    Congestive Heart Failure a leading cause of morbidity and mortality is often associated with comorbidities and with it polypharmacy. Improved pathophysiological understanding, the available therapeutics, clinical guidelines and structured programs for comprehensive care have not benefited all clients in the Northern Territory of Australia. The Northern Territory has both a unique geography and demography including a sizeable Indigenous population. Additional factors that can affect heart failure management are prevalent in remote areas and are not well addressed within randomized controlled trials. This review is focused on building a case for widening the therapeutic paradigm for heart failure with comorbidities. We focus on a brief overview of heart failure and its associated comorbidities, the common overlapping physiological processes, the interpretation of the external validity of trial evidence, and finally exploring the available evidence for the important therapies within the guidelines. A need to consider a wider therapeutic paradigm may also have relevance for clients in other health systems.
    Original languageEnglish
    Article number106
    Pages (from-to)1-9
    Number of pages9
    JournalHealth Care: Current Reviews
    Volume1
    Issue number1
    DOIs
    Publication statusPublished - 2013

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    Comorbidity
    Heart Failure
    Northern Territory
    Guidelines
    Physiological Phenomena
    Polypharmacy
    Geography
    Therapeutics
    Population Groups
    Randomized Controlled Trials
    Demography
    Morbidity
    Mortality
    Health

    Cite this

    Iyngkaran, P., M., T., Sanders, P., Hare, D. L., Majoni, S. W., Brady, S., ... Brown, A. (2013). Do We Need A Wider Therapeutic Paradigm For Heart Failure With Comorbidities? A Remote Australian Perspective. Health Care: Current Reviews, 1(1), 1-9. [106]. https://doi.org/10.4172/hccr.1000106
    Iyngkaran, Pupalan ; M., Thomas ; Sanders, Prashanthan ; Hare, D.L ; Majoni, Sandawana William ; Brady, Stephen ; Nadarajan , K ; ILTON, Marcus ; Brown, A. / Do We Need A Wider Therapeutic Paradigm For Heart Failure With Comorbidities? A Remote Australian Perspective. In: Health Care: Current Reviews. 2013 ; Vol. 1, No. 1. pp. 1-9.
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    abstract = "Congestive Heart Failure a leading cause of morbidity and mortality is often associated with comorbidities and with it polypharmacy. Improved pathophysiological understanding, the available therapeutics, clinical guidelines and structured programs for comprehensive care have not benefited all clients in the Northern Territory of Australia. The Northern Territory has both a unique geography and demography including a sizeable Indigenous population. Additional factors that can affect heart failure management are prevalent in remote areas and are not well addressed within randomized controlled trials. This review is focused on building a case for widening the therapeutic paradigm for heart failure with comorbidities. We focus on a brief overview of heart failure and its associated comorbidities, the common overlapping physiological processes, the interpretation of the external validity of trial evidence, and finally exploring the available evidence for the important therapies within the guidelines. A need to consider a wider therapeutic paradigm may also have relevance for clients in other health systems.",
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    Iyngkaran, P, M., T, Sanders, P, Hare, DL, Majoni, SW, Brady, S, Nadarajan , K, ILTON, M & Brown, A 2013, 'Do We Need A Wider Therapeutic Paradigm For Heart Failure With Comorbidities? A Remote Australian Perspective.', Health Care: Current Reviews, vol. 1, no. 1, 106, pp. 1-9. https://doi.org/10.4172/hccr.1000106

    Do We Need A Wider Therapeutic Paradigm For Heart Failure With Comorbidities? A Remote Australian Perspective. / Iyngkaran, Pupalan; M., Thomas; Sanders, Prashanthan; Hare, D.L; Majoni, Sandawana William; Brady, Stephen; Nadarajan , K; ILTON, Marcus; Brown, A.

    In: Health Care: Current Reviews, Vol. 1, No. 1, 106, 2013, p. 1-9.

    Research output: Contribution to journalReview articleResearchpeer-review

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    AU - Majoni, Sandawana William

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