Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona

Jolene Bowers, Elizabeth Driebe, Jennifer Nibecker, Bette Wojack, Derek Sarovich, Ada Wong, Pius Brzoska, Nathaniel Hubert, Andrew Knadler, Lindsey Watson, David M Wagner, Manohar Furtado, Michael Saubolle, David M Engelthaler, Paul S Keim

    Research output: Contribution to journalArticle

    9 Downloads (Pure)

    Abstract

    Background: Rates of resistance to macrolide antibiotics in Streptococcus pneumoniae are rising around the world due to the spread of mobile genetic elements harboring mef(E) and erm(B) genes and post-vaccine clonal expansion of strains that carry them.

    Results: Characterization of 592 clinical isolates collected in Arizona over a 10 year period shows 23.6% are macrolide resistant. The largest portion of the macrolide-resistant population, 52%, is dual mef(E)/erm(B)-positive. All dual-positive isolates are multidrug-resistant clonal lineages of Taiwan19F-14, mostly multilocus sequence type 320, carrying the recently described transposon Tn2010. The remainder of the macrolide resistant S. pneumoniae collection includes 31% mef(E)-positive, and 9% erm(B)-positive strains.

    Conclusions: The dual-positive, multidrug-resistant S. pneumoniae clones have likely expanded by switching to non-vaccine serotypes after the heptavalent pneumococcal conjugate vaccine release, and their success limits therapy options. This upsurge could have a considerable clinical impact in Arizona.
    Original languageEnglish
    Pages (from-to)1-10
    Number of pages10
    JournalBMC Microbiology
    Volume12
    DOIs
    Publication statusPublished - 2012

    Fingerprint Dive into the research topics of 'Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona'. Together they form a unique fingerprint.

    Cite this