Abstract
Background: Antimicrobial doses in children are often prescribed by using an individually calculated dose per weight (e.g., mg/kg) or based on body surface area. Dosing errors are the most commonly reported medication errors in children. A "dose-banding" strategy is frequently used for some over-the-counter drugs to prevent dosing errors. It could also lead to efficiencies by enabling batch preparation of intravenous (IV) medications in hospitals.
Objectives: To evaluate whether use of dose-banding for IV
piperacillin-tazobactam results in acceptable dose variation from standard
practice of individualized prescription of 100 mg/kg in children.
Methods: We conducted a historically controlled intervention
study comparing prescriptions of IV piperacillin-tazobactam before vs. after
introduction of dose-banding prescribing guidance for surgical inpatients
weighing >5 kg and 30% variation from the 100-mg/kg dose) in the dose-banded
compared to the non-dose-banded group (1/140 vs. 5/105; p = 0.09).
Conclusions: Our study
showed dose-banding of IV piperacillin-tazobactam resulted in acceptable
variation when compared to individualized milligram-per-weight dosing in
children. Prospectively designed controlled trials are warranted to determine
whether dose-banding could reduce medication errors and optimize use of
hospital resources. Implications for future practice could include faster batch
preparation, shorter checking and dispensing time, and reduction in drug
wastage.
Original language | English |
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Pages (from-to) | 364-368 |
Number of pages | 5 |
Journal | The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG |
Volume | 22 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 Sep 2017 |