Economic Burden Attributed to Children Presenting to Hospitals with Hand, Foot, and Mouth Disease in Vietnam

Le Nguyen Thanh Nhan, Hugo C. Turner, Truong Huu Khanh, Nguyen Thanh Hung, Le Bich Lien, Nguyen Thi Thu Hong, Le Nguyen Truc Nhu, Nguyen Thi Han Ny, Lam Anh Nguyet, Tran Tan Thanh, Hoang Minh Tu Van, Ho Lu Viet, Trinh Huu Tung, Tran Thi Lan Phuong, Angela Devine, Guy Thwaites, Nguyen Van Vinh Chau, Louise Thwaites, H. Rogier Van Doorn, Le Van Tan

Research output: Contribution to journalArticlepeer-review

4 Downloads (Pure)


Hand, foot, and mouth disease (HFMD) has become a major public health concern in the Asia-Pacific region. Knowledge of its economic burden is essential for policy makers in prioritizing the development and implementation of interventions. Methods: A multi-hospital-based study was prospectively conducted at 3 major hospitals in Ho Chi Minh City, Vietnam, during 2016-2017. Data on direct and productivity costs were collected alongside clinical information and samples and demographic information from study participants. Results: A total of 466 patients were enrolled. Two hundred three of 466 (43.6%) patients lived in Ho Chi Minh City, and 72/466 (15.5%) had severe HFMD. An enterovirus was identified in 74% of 466 patients, with EV-A71, CV-A6, CV-A10, and CV-A16 being the most common viruses identified (236/466, 50.6%). The mean economic burden per case was estimated at US$400.80 (95% confidence interval [CI], $353.80-$448.90), of which the total direct (medical) costs accounted for 69.7%. There were considerable differences in direct medical costs between groups of patients with different clinical severities and pathogens (ie, EV-A71 vs non-EV-A71). In Vietnam, during 2016-2017, the economic burden posed by HFMD was US$90 761 749 (95% CI, $79 033 973-$103 009 756). Conclusions: Our findings are of public health significance because for the first time we demonstrate that HFMD causes a substantial economic burden in Vietnam, and although multivalent vaccines are required to control HFMD, effective EV-A71 vaccine could substantially reduce the burden posed by severe HFMD. The results will be helpful for health policy makers in prioritizing resources for the development and implementation of intervention strategies to reduce the burden of HFMD.

Original languageEnglish
Article numberofz284
Pages (from-to)1-7
Number of pages7
JournalOpen Forum Infectious Diseases
Issue number7
Publication statusPublished - 1 Jul 2019
Externally publishedYes


Dive into the research topics of 'Economic Burden Attributed to Children Presenting to Hospitals with Hand, Foot, and Mouth Disease in Vietnam'. Together they form a unique fingerprint.

Cite this