Effect of aerobic exercise on leptin and PGC-1a gene expression in a unique cohort of morbidly obese Polynesians with Type 2 diabetes

Irum Hayat; David Rowlands; Isabelle Lys; William Sukala; Birinder Cheema; Bernhard Breier; Murray Leikis; Jeremy Krebs; Rachel Page

doi:10.1093/edrv/33.supp.1

Effect of aerobic exercise on leptin and PGC-1a gene expression in a unique cohort of morbidly obese Polynesians with Type 2 diabetes

Irum Hayat, David Rowlands, Isabelle Lys, William Sukala, Birinder Cheema, Bernhard Breier, Murray Leikis, Jeremy Krebs, Rachel Page

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Incidence of type 2 diabetes (T2D) and obesity is rapidly escalating in New Zealand, particularly in Polynesians. Aerobic (AER) exercise can improve body composition, glycaemic control, and alter circulating metabolic hormones in individuals with T2D. PGC-1α is a key regulator in energy metabolism, controlling adaptive thermogenesis and glucose/fatty acid metabolism, and has been implicated in the pathogenesis of T2D. We have a unique cohort of morbidly obese Polynesian New Zealanders with T2D that have undergone intensive exercise training in the SPIRIT study. We are interested in examining the impact of exercise on energy metabolism in the skeletal muscle (SM) of this unique cohort.

Original language	English
Pages (from-to)	-
Journal	Endocrine Reviews
Volume	33
Issue number	3_Supplement
DOIs	https://doi.org/10.1093/edrv/33.supp.1
Publication status	Published - 2012

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10.1093/edrv/33.supp.1

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abstract = "Incidence of type 2 diabetes (T2D) and obesity is rapidly escalating in New Zealand, particularly in Polynesians. Aerobic (AER) exercise can improve body composition, glycaemic control, and alter circulating metabolic hormones in individuals with T2D. PGC-1α is a key regulator in energy metabolism, controlling adaptive thermogenesis and glucose/fatty acid metabolism, and has been implicated in the pathogenesis of T2D. We have a unique cohort of morbidly obese Polynesian New Zealanders with T2D that have undergone intensive exercise training in the SPIRIT study. We are interested in examining the impact of exercise on energy metabolism in the skeletal muscle (SM) of this unique cohort.",

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T1 - Effect of aerobic exercise on leptin and PGC-1a gene expression in a unique cohort of morbidly obese Polynesians with Type 2 diabetes

AU - Hayat, Irum

AU - Rowlands, David

AU - Lys, Isabelle

AU - Sukala, William

AU - Cheema, Birinder

AU - Breier, Bernhard

AU - Leikis, Murray

AU - Krebs, Jeremy

AU - Page, Rachel

PY - 2012

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N2 - Incidence of type 2 diabetes (T2D) and obesity is rapidly escalating in New Zealand, particularly in Polynesians. Aerobic (AER) exercise can improve body composition, glycaemic control, and alter circulating metabolic hormones in individuals with T2D. PGC-1α is a key regulator in energy metabolism, controlling adaptive thermogenesis and glucose/fatty acid metabolism, and has been implicated in the pathogenesis of T2D. We have a unique cohort of morbidly obese Polynesian New Zealanders with T2D that have undergone intensive exercise training in the SPIRIT study. We are interested in examining the impact of exercise on energy metabolism in the skeletal muscle (SM) of this unique cohort.

AB - Incidence of type 2 diabetes (T2D) and obesity is rapidly escalating in New Zealand, particularly in Polynesians. Aerobic (AER) exercise can improve body composition, glycaemic control, and alter circulating metabolic hormones in individuals with T2D. PGC-1α is a key regulator in energy metabolism, controlling adaptive thermogenesis and glucose/fatty acid metabolism, and has been implicated in the pathogenesis of T2D. We have a unique cohort of morbidly obese Polynesian New Zealanders with T2D that have undergone intensive exercise training in the SPIRIT study. We are interested in examining the impact of exercise on energy metabolism in the skeletal muscle (SM) of this unique cohort.

UR - https://researchdirect.westernsydney.edu.au/islandora/object/uws:40524

U2 - 10.1093/edrv/33.supp.1

DO - 10.1093/edrv/33.supp.1

M3 - Meeting Abstract

SN - 0163-769X

VL - 33

SP - -

JO - Endocrine Reviews

JF - Endocrine Reviews

IS - 3_Supplement

ER -

Effect of aerobic exercise on leptin and PGC-1a gene expression in a unique cohort of morbidly obese Polynesians with Type 2 diabetes

Abstract

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