Effect of cations on the microstructure and in-vitro drug release of κ- And ι-carrageenan liquid and semi-solid aqueous dispersions

Thilini Rasika Thrimawithana, Simon Young, Raid G. Alany

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: The main objective of this study was to determine the effect of potassium and calcium ions on the microstructure and release dynamics of kappa (κ) and iota (ι) carrageenan. 

Methods The microstructure of the dispersions was imaged using a cryogenic scanning electron microscope. Franz-cell diffusion apparatus was used to determine the release kinetics of a model hydrophilic drug, sodium fluorescein, incorporated in selected polymer dispersions. Release profiles were analysed using Higuchi, Korsmeyer-Peppas and dual first-order models. 

Key Findings Cryogenic scanning electron microscope images showed that κ-carrageenan forms hexagonal structures, whereas ι-carrageenan forms rectangular pores at low cation concentrations. In-vitro release studies showed sustained release profiles for all carrageenan systems; however the model drug, fluorescein, diffusion from ι-carrageenan with 0.06% w/v calcium was significantly higher than other ι-carrageenan systems. This may be attributed to improved tortuosity of this system. However further increase in cation concentration led to a reduction in fluorescein release from the matrices. The dual first-order release model illustrated two distinct release rates, an initial rapid release followed by a slow diffusion of fluorescein from the carrageenan matrices. 

Conclusions The observed microstructural differences may account for the well known variation in mechanical properties of κ- and ι-carrageenan gels. The dual first order release model adds a new tool in the elucidation of release mechanisms from polymer matrices, where parallel processes contribute to drug release.

Original languageEnglish
Pages (from-to)11-18
Number of pages8
JournalJournal of Pharmacy and Pharmacology
Volume63
Issue number1
DOIs
Publication statusPublished - Jan 2011
Externally publishedYes

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