Abstract
Objective: To identity the effect of exercise on brain metabolism and energetics in PD using PET/MR imaging.
Background: Aerobic exercise slows PD progression as reflected clinically [1]. Mitochondrial dysfunction may play a role in the onset and progression of PD, and aerobic exercise may positively modulate mitochondrial dynamics [2]. PET/MR imaging can be used to obtain simultaneously cerebral metabolic rates of oxygen (CMRO2) and glucose (CMRglu); estimates of mitochondrial function can be inferred through the oxygen-to-glucose ratio.
Method: An ongoing study is performing dual-calibrated BOLD MRI and FDG PET imaging to obtain CMRO2 and CMRglu in PD habitual exercisers (PD-HE, n=4) and PD non-exercisers (PD-NE) before (n=6) and after (n=4) six-month stationary cycling. Constrained principal component analysis (CPCA) [3] is used to identify disease- and exercise-related spatial patterns of regional CMRO2 and CMRglu. CPCA first regresses Z, the spatially-normalized imaging measures for each subject, onto clinical variables, X, related to disease (disease duration (DD), UPDRS-III) and aerobic fitness (VO2 max), i.e. Z ≈ XC, where C are the regression coefficients. Standard PCA is then run on XC to obtain spatial patterns rank-ordered by their explanation of the variance-of-interest contained in XC.
Results: Subject scores of the first CMRglu CPCA pattern are significantly higher in the PD-NE pre-intervention compared to PD-HE (p
Conclusion: A pattern of glucose metabolism positively related to DD and negatively related to aerobic fitness was found. Group differences of pattern expression between a small cohort of PD non-exercisers before and after aerobic exercise suggests causality between exercise and disease progression. More subjects will be added as they complete the intervention. Joint CMRglu and CMRO2 pattern analysis will follow.
Background: Aerobic exercise slows PD progression as reflected clinically [1]. Mitochondrial dysfunction may play a role in the onset and progression of PD, and aerobic exercise may positively modulate mitochondrial dynamics [2]. PET/MR imaging can be used to obtain simultaneously cerebral metabolic rates of oxygen (CMRO2) and glucose (CMRglu); estimates of mitochondrial function can be inferred through the oxygen-to-glucose ratio.
Method: An ongoing study is performing dual-calibrated BOLD MRI and FDG PET imaging to obtain CMRO2 and CMRglu in PD habitual exercisers (PD-HE, n=4) and PD non-exercisers (PD-NE) before (n=6) and after (n=4) six-month stationary cycling. Constrained principal component analysis (CPCA) [3] is used to identify disease- and exercise-related spatial patterns of regional CMRO2 and CMRglu. CPCA first regresses Z, the spatially-normalized imaging measures for each subject, onto clinical variables, X, related to disease (disease duration (DD), UPDRS-III) and aerobic fitness (VO2 max), i.e. Z ≈ XC, where C are the regression coefficients. Standard PCA is then run on XC to obtain spatial patterns rank-ordered by their explanation of the variance-of-interest contained in XC.
Results: Subject scores of the first CMRglu CPCA pattern are significantly higher in the PD-NE pre-intervention compared to PD-HE (p
Conclusion: A pattern of glucose metabolism positively related to DD and negatively related to aerobic fitness was found. Group differences of pattern expression between a small cohort of PD non-exercisers before and after aerobic exercise suggests causality between exercise and disease progression. More subjects will be added as they complete the intervention. Joint CMRglu and CMRO2 pattern analysis will follow.
| Original language | English |
|---|---|
| Publication status | Published - 2022 |
| Event | 2022 International Congress - Madrid, Spain Duration: 15 Sept 2022 → 18 Sept 2022 https://www.mdsabstracts.org/meetings/2022-international-congress/?alpha= |
Conference
| Conference | 2022 International Congress |
|---|---|
| Country/Territory | Spain |
| City | Madrid |
| Period | 15/09/22 → 18/09/22 |
| Internet address |