Effective loading of cisplatin into a nanoscale UiO-66 metal-organic framework with preformed defects

Shi Xin Lin, Wei Lun Pan, Ru Jie Niu, Yan Liu, Jin Xiang Chen, Wen Hua Zhang, Jian Ping Lang, David J. Young

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Defects within the nanoscale UiO-66 metal-organic framework (MOF) are created to lock a hybrid phosphonoacetate ligand through Zr-O-P linkages, leaving the carboxyl group free to anchor cisplatin prodrug cis, cis, trans-[Pt(NH 3 ) 2 Cl 2 (OH) 2 ]. A drug loading of 256.5 mg g −1 (25.7 wt% based on cisplatin) was achieved with a Zr 6  : Pt : P ratio of 1.5 : 1 : 1, which surpasses defect-free UiO-66 and several other MOF carriers. This framework exhibited a burst release of its payload in PBS solution in the first 2 h, releasing 71% of the drug, including a 50% payload release in less than 1 h. This work demonstrates that MOF defects can be intentionally engineered to achieve a high drug loading, and serves as an alternative to drug encapsulation using the pore void and through the association of the functionalized ligand.

Original languageEnglish
Pages (from-to)5308-5314
Number of pages7
JournalDalton Transactions
Volume48
Issue number16
Early online date26 Mar 2019
DOIs
Publication statusPublished - 28 Apr 2019

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Cisplatin
Metals
Defects
Pharmaceutical Preparations
Phosphonoacetic Acid
Ligands
Prodrugs
Anchors
Encapsulation

Cite this

Lin, Shi Xin ; Pan, Wei Lun ; Niu, Ru Jie ; Liu, Yan ; Chen, Jin Xiang ; Zhang, Wen Hua ; Lang, Jian Ping ; Young, David J. / Effective loading of cisplatin into a nanoscale UiO-66 metal-organic framework with preformed defects. In: Dalton Transactions. 2019 ; Vol. 48, No. 16. pp. 5308-5314.
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abstract = "Defects within the nanoscale UiO-66 metal-organic framework (MOF) are created to lock a hybrid phosphonoacetate ligand through Zr-O-P linkages, leaving the carboxyl group free to anchor cisplatin prodrug cis, cis, trans-[Pt(NH 3 ) 2 Cl 2 (OH) 2 ]. A drug loading of 256.5 mg g −1 (25.7 wt{\%} based on cisplatin) was achieved with a Zr 6  : Pt : P ratio of 1.5 : 1 : 1, which surpasses defect-free UiO-66 and several other MOF carriers. This framework exhibited a burst release of its payload in PBS solution in the first 2 h, releasing 71{\%} of the drug, including a 50{\%} payload release in less than 1 h. This work demonstrates that MOF defects can be intentionally engineered to achieve a high drug loading, and serves as an alternative to drug encapsulation using the pore void and through the association of the functionalized ligand.",
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Effective loading of cisplatin into a nanoscale UiO-66 metal-organic framework with preformed defects. / Lin, Shi Xin; Pan, Wei Lun; Niu, Ru Jie; Liu, Yan; Chen, Jin Xiang; Zhang, Wen Hua; Lang, Jian Ping; Young, David J.

In: Dalton Transactions, Vol. 48, No. 16, 28.04.2019, p. 5308-5314.

Research output: Contribution to journalArticleResearchpeer-review

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