Effective loading of cisplatin into a nanoscale UiO-66 metal-organic framework with preformed defects

Shi Xin Lin, Wei Lun Pan, Ru Jie Niu, Yan Liu, Jin Xiang Chen, Wen Hua Zhang, Jian Ping Lang, David J. Young

Research output: Contribution to journalArticle

Abstract

Defects within the nanoscale UiO-66 metal-organic framework (MOF) are created to lock a hybrid phosphonoacetate ligand through Zr-O-P linkages, leaving the carboxyl group free to anchor cisplatin prodrug cis, cis, trans-[Pt(NH 3 ) 2 Cl 2 (OH) 2 ]. A drug loading of 256.5 mg g −1 (25.7 wt% based on cisplatin) was achieved with a Zr 6  : Pt : P ratio of 1.5 : 1 : 1, which surpasses defect-free UiO-66 and several other MOF carriers. This framework exhibited a burst release of its payload in PBS solution in the first 2 h, releasing 71% of the drug, including a 50% payload release in less than 1 h. This work demonstrates that MOF defects can be intentionally engineered to achieve a high drug loading, and serves as an alternative to drug encapsulation using the pore void and through the association of the functionalized ligand.

Original languageEnglish
Pages (from-to)5308-5314
Number of pages7
JournalDalton Transactions
Volume48
Issue number16
Early online date26 Mar 2019
DOIs
Publication statusPublished - 28 Apr 2019

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    Lin, S. X., Pan, W. L., Niu, R. J., Liu, Y., Chen, J. X., Zhang, W. H., Lang, J. P., & Young, D. J. (2019). Effective loading of cisplatin into a nanoscale UiO-66 metal-organic framework with preformed defects. Dalton Transactions, 48(16), 5308-5314. https://doi.org/10.1039/C9DT00719A