TY - JOUR
T1 - Effectiveness of a cough management algorithm at the transitional phase from acute to chronic cough in Australian children aged <15 years
T2 - Protocol for a randomised controlled trial
AU - O'Grady, Kerry Ann F
AU - Grimwood, Keith
AU - Toombs, Maree
AU - Sloots, Theo P
AU - Otim, Michael
AU - Whiley, David M
AU - Anderson, Jennie
AU - Rablin, Sheree
AU - Torzillo, Paul J.
AU - Buntain, Helen
AU - Connor, Anne
AU - Adsett, Don
AU - Meng kar, Oon
AU - Chang, Anne B.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Introduction: Acute respiratory infections (ARIs) are leading causes of hospitalisation in Australian children and, if recurrent, are associated with increased risk of chronic pulmonary disorders later in life. Chronic (>4â €..weeks) cough in children following ARI is associated with decreased quality-of-life scores and increased health and societal economic costs. We will determine whether a validated evidence-based cough algorithm, initiated when chronic cough is first diagnosed after presentation with ARI, improves clinical outcomes in children compared with usual care. Methods and analysis: A multicentre, parallel group, open-label, randomised controlled trial, nested within a prospective cohort study in Southeast Queensland, Australia, is underway. 750 children aged <15â €..years will be enrolled and followed weekly for 8â €..weeks after presenting with an ARI with cough. 214 children from this cohort with persistent cough at day 28 will be randomised to either early initiation of a cough management algorithm or usual care (107 per group). Randomisation is stratified by reason for presentation, site and total cough duration at day 28 (<6 and ≥6â €..weeks). Demographic details, risk factors, clinical histories, examination findings, cost-of-illness data, an anterior nasal swab and parent and child exhaled carbon monoxide levels (when age appropriate) are collected at enrolment. Weekly contacts will collect cough status and cost-of-illness data. Additional nasal swabs are collected at days 28 and 56. The primary outcome is time-To-cough resolution. Secondary outcomes include direct and indirect costs of illness and the predictors of chronic cough postpresentation. Ethics and dissemination: The Children's Health Queensland (HREC/15/QRCH/15) and the Queensland University of Technology University (1500000132) Research Ethics Committees have approved the study. The study will inform best-practice management of cough in children. Trial registration number: ACTRN12615000132549.
AB - Introduction: Acute respiratory infections (ARIs) are leading causes of hospitalisation in Australian children and, if recurrent, are associated with increased risk of chronic pulmonary disorders later in life. Chronic (>4â €..weeks) cough in children following ARI is associated with decreased quality-of-life scores and increased health and societal economic costs. We will determine whether a validated evidence-based cough algorithm, initiated when chronic cough is first diagnosed after presentation with ARI, improves clinical outcomes in children compared with usual care. Methods and analysis: A multicentre, parallel group, open-label, randomised controlled trial, nested within a prospective cohort study in Southeast Queensland, Australia, is underway. 750 children aged <15â €..years will be enrolled and followed weekly for 8â €..weeks after presenting with an ARI with cough. 214 children from this cohort with persistent cough at day 28 will be randomised to either early initiation of a cough management algorithm or usual care (107 per group). Randomisation is stratified by reason for presentation, site and total cough duration at day 28 (<6 and ≥6â €..weeks). Demographic details, risk factors, clinical histories, examination findings, cost-of-illness data, an anterior nasal swab and parent and child exhaled carbon monoxide levels (when age appropriate) are collected at enrolment. Weekly contacts will collect cough status and cost-of-illness data. Additional nasal swabs are collected at days 28 and 56. The primary outcome is time-To-cough resolution. Secondary outcomes include direct and indirect costs of illness and the predictors of chronic cough postpresentation. Ethics and dissemination: The Children's Health Queensland (HREC/15/QRCH/15) and the Queensland University of Technology University (1500000132) Research Ethics Committees have approved the study. The study will inform best-practice management of cough in children. Trial registration number: ACTRN12615000132549.
KW - children
KW - chronic cough
KW - cost effectiveness
KW - intervention
KW - randomised controlled trial
UR - http://www.scopus.com/inward/record.url?scp=85014908281&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2016-013796
DO - 10.1136/bmjopen-2016-013796
M3 - Article
C2 - 28259853
VL - 7
SP - 1
EP - 12
JO - BMJ Open
JF - BMJ Open
SN - 2044-6055
IS - 3
M1 - e013796
ER -